Results 111 to 120 of about 2,247,745 (314)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A comparative study of modified performance based plastic design methods for seismic design of RC frames: improvement over existing methods

open access: yesScientific Reports
This study introduces a Modified Performance-Based Plastic Design (MPBPD) method to enhance the seismic performance of reinforced concrete special moment-resisting frames.
Rohit Vyas   +10 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The evaluation performance of letter-based technique on text steganography system

open access: yes, 2019
Steganography is a part of information hiding in covering the hidden message in any medium such as text, image, audio, video and others. This paper concerns about the implementation of steganography in text domain called text steganography. It intends to
Capacity of size bit   +3 more
core   +1 more source

EVALUATION OF PERFORMANCE OF ASYMMETRICALLY DUAL SYSTEM STRUCTURES USING PUSHOVER AND TIME HISTORY ANALYSES

open access: yesJournal of Civil Engineering
Performance-based design is becoming increasingly popular in designing a seismic resistant building. In the study, a twelvestory, reinforced concrete office building with asymmetric configuration using dual system located in seismic zone 6 was designed ...
Kurdian Suprapto, Sudarto Sudarto
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Developing a current capability design for manufacture framework in the aerospace industry [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityDuring progressive product design and development in the aerospace industry, a lack of effective communication between the sequential functions of design, manufacturing and assembly often causes delays and setbacks ...
Shehab, Essam   +3 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Identifying Risk and its Impact on Contracting Through a Benefit Based-Model Framework in Business to Business contracting: Case of the defence industry [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityTwo defence contracts for availability are studied in the attempt to better understanding the provision of service in a maintenance, repair and overhaul environment that is contracted on the performance of the ...
Yip, N., Ng, I.C.L., Yip, Nick, Ng, I.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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