Results 91 to 100 of about 2,247,745 (314)

PERFORMANCE BASED DESIGN OF EARTH RETAINING STRUCTURES AND BUILDING CODES

, 2012
The design of a geotechnical structure under seismic loading is frequently carried out by means of the pseudostatic approach, checking the system against any possible geotechnical and structural ultimate limit states.
SEGATO, David, SCARPELLI, Giuseppe, RUGGERI, PAOLO, VITA, ALESSANDRO, FRUZZETTI, Viviene Marianne Esther   +4 more
core  

How to Answer to the Challenges of Competencies Management in Collaborative Product Design? [PDF]

, 2009
Organised by: Cranfield UniversityCollaboration is an essential factor of the design activities performance. This collaboration occurs between actors suited with varied expertises, coming from various trades and thus building a real network around the ...
Robin, V., Rose, B., Sperandio, S.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

(Value, Risk)-based Performance Evaluation of Manufacturing Processes [PDF]

, 2012
A value/risk -based performance evaluation framework is proposed in the context of manufacturing processes at the industrialization phase of product development.
SHAH, Liaqat, SIADAT, Ali, VERNADAT, François, ETIENNE, Alain   +3 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Performance Based Abstraction of Biomimicry Design Principles using Prototyping

Designs, 2019
A key challenge faced by biomimicry practitioners is making the conceptual leap between biology and design, particularly regarding collaborating across these knowledge domains and developing and evaluating design principles abstracted from biology. While
Erin Rovalo, John McCardle
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A performance-based generative design framework based on a design grammar for high-rise office towers during early design stage

Frontiers of Architectural Research
In the past decade, the construction speed of high-rise office towers worldwide has exhibited explosive growth. The unique morphological characteristics of high-rise office towers result in higher shape factors and relatively larger thermal loads.
Liwei Chen, Ye Zhang, Yue Zheng
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source