Results 131 to 140 of about 24,225,267 (339)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Calibrated Weighting for Small Area Estimation

open access: yes, 2005
Calibrated weighting methods for estimation of survey population characteristics are widely used. At the same time, model-based prediction methods for estimation of small area or domain characteristics are becoming increasingly popular.
Chambers, R. L.
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Validation of an Automated High-Throughput Multiplex Real-Time PCR Assay for Detection of Enteric Protozoa

open access: yesHygiene
Background: Microscopy is the conventional method for the identification of gastrointestinal parasitic pathogens in fecal specimens; however, it presents numerous challenges, including high technical expertise burden, multiple staining procedures, and ...
Rachel Lau   +7 more
doaj   +1 more source

A submillimeter interference spectrometer - Characteristics, performance and measurements [PDF]

open access: yes
Performance characteristics of interference spectrometer using submillimeter ...
Breeden, K. H.   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Board Characteristics and Corporate Performance in the Netherlands [PDF]

open access: yes
We analyze the performance-board characteristic nexus of Dutch listed firms. The Netherlands has a continental-European two-tier board structure. This makes it interesting to analyze the impact of management and supervisory board characteristics (size ...
Elmer Sterken   +2 more
core  

Performance of silicon solar cell assemblies [PDF]

open access: yes, 1972
Solar cell assembly current-voltage characteristics, thermal-optical properties, and power performance were determined. Solar cell cover glass thermal radiation, optical properties, confidence limits, and temperature intensity effects on maximum power ...
Cleland, E. L.   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Comparison of 16S rDNA-PCR amplification and culture of cerebrospinal fluid for diagnosis of bacterial meningitis

open access: yesJournal of Mazandaran University of Medical Sciences, 2009
(Received 29 Nov, 2008 ; Accepted 8 Apr, 2009)AbstractBackground and purpose: Early and accurate diagnosis of bacterial meningitis is critical concern. Optimum and rapid laboratory facilities are not routinely available for detecting the etiologic agents
Mohammad Reza Sarokhani   +5 more
doaj  

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