Results 141 to 150 of about 3,037,170 (287)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Relación entre el mérito genético para la producción de leche y el desempeño metabólico y reproductivo en la vaca de alta producción Relations among the genetic merit to milk yield and metabolic and reproductive performance of high production cows

Revista Colombiana de Ciencias Pecuarias, 2005
A la vez que ha aumentado la ganancia genética para la producción de leche, el desempeño reproductivo de las vacas ha desmejorado simultáneamente; sin embargo, las razones fisiológicas de este antagonismo no están bien determinadas.
Rubén D Galvis, Edwin A Múnera, Andres M Marín   +2 more
doaj  

Contrôle de la performance, pression des pairs et régulation de la coopération. De l'interaction à l'institution. [PDF]

, 2006
International audienceLa littérature managériale fait généralement de l'allocation des ressources et de son contrôle les éléments explicatifs majeurs du niveau de performance atteint par une organisation.
Véran, Lucien
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Desempenho produtivo de juvenis de tambaqui (Colossoma macropomum Cuvier, 1818) alimentados com rações contendo farinha de crueira de mandioca (Manihot esculenta, Crantz) em substituição ao milho (Zea mays) Performance of juvenile tambaqui (Colossoma macropomum Cuvier, 1818) fed diets containing crueira manioc flour (Manihot esculenta, Crantz) in replacement of corn (Zea mays)

Acta Amazonica, 2013
O objetivo deste estudo foi avaliar o desempenho produtivo de juvenis de tambaqui (Colossoma macropomum), alimentados com níveis crescentes de farinha de crueira de mandioca, Manihot esculenta (0%, 20%, 40%, 60%, 80%, 100%), como substituto do milho (Zea
Geraldo Pereira Pereira Junior, Expedita Maria de Oliveira Pereira, Manoel Pereira Filho, Paula de Sousa Barbosa, Eduardo Shimoda, Lian Valente Brandão   +5 more
doaj  

D'un pilotage intégré de la performance vers des outils de performance par le changement organisationnel : Mise en oeuvre de dispositifs cliniques et ERP [PDF]

L'article met en évidence le rôle joué par les ERP dans le pilotage de la performance. Grâce à une méthodologie qualitative, il met en lumière que les fonctionnalités apportées par les ERP ne sont pas le seul élément crucial dans la mise en place d'un ...
Azan Wilfrid
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source