Results 161 to 170 of about 69,653,451 (303)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Growth performance, carcass traits, and breast meat quality of slow-growing broiler strains reared in a free-range system: effects of genotype and sex at different slaughter ages. [PDF]

Trop Anim Health Prod
Lacerda MB, Valentim JK, de Almeida Torres Filho R, de Araújo CV, Silva RA, Romanelli EV, Boari CA, de Almeida AA, Pinheiro SRF.   +8 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Cassava by-products in broiler diets: effects on growth performance based on a systematic review. [PDF]

Trop Anim Health Prod
Matte WD, Zeferino CP, da Silva HM, Valentim JK, Pereira MMC, Nabhan MEV, Silva LC, Sgavioli S.   +7 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Multifunctional Rhizobacterial Consortia Enhance Growth and Yield of Common Bean Across Field Conditions. [PDF]

Environ Microbiol Rep
Oliveira APS, Mirza CCR, Sousa CM, Ferreira EPB.   +3 more
europepmc   +1 more source

Analyse des performances d'un atelier de production discontinue : méthode et logiciel

, 1993
Nous nous intéressons aux ateliers de production électronique soumis à aléas. Deux types d'aléas sont considérés : les pannes de machines et les rebuts dus à la mauvaise qualité des produits. Nous modélisons la structure d'un atelier à l'aide des réseaux de Petri paramétrés et proposons une analyse en deux étapes.
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Partial Replacement of Corn with Jackfruit Silage Maintains Productive Performance and Carcass Characteristics of Feedlot Lambs. [PDF]

Animals (Basel)
Salt MPF, Nascimento LS, Rodrigues HP, Ferreira JMS, Souza LL, Cruz CLDS, Silva RR, Carvalho GGP, Santos SA, Cabral ÍDS, Almeida FM, Azevêdo JAG.   +11 more
europepmc   +1 more source