Results 161 to 170 of about 3,037,170 (287)

Effect of weaning age on pregnancy rates in Braford beef heifers bred at 13 months. [PDF]

Anim Reprod
Dallanóra MEC, Lobato JFP, Bethancourt-Garcia JA, Borges MA, Pacheco RF, Restle J, Vaz RZ.   +6 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Heat stress in livestock under tropical climates: impacts and mitigation strategies. [PDF]

Trop Anim Health Prod
Jongbo AO, de Borba LP, Pereira RMM, Bello QO, Gregoratto LL, de Souza DP, Adeyeye OA, Vieira FMC.   +7 more
europepmc   +1 more source

Analyse des performances d'un atelier de production discontinue : méthode et logiciel

, 1993
Nous nous intéressons aux ateliers de production électronique soumis à aléas. Deux types d'aléas sont considérés : les pannes de machines et les rebuts dus à la mauvaise qualité des produits. Nous modélisons la structure d'un atelier à l'aide des réseaux de Petri paramétrés et proposons une analyse en deux étapes.
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Nitrogen Source-Carbohydrate Synchronization in Ruminant Nutrition: A Systematic Review. [PDF]

Animals (Basel)
Bezerra LR, Oliveira JPF, Vaz AFM, Lucena KHOS, Barros LS, Fortunato YMA, Gonzaga Neto S, Pereira ES, Oliveira RL, Pereira Filho JM.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Photochemical Efficiency and Leaf Carbohydrates of Theobroma cacao L. Genotypes Under Different Light Regimes and Cultivation Systems. [PDF]

Plants (Basel)
da Vitória J, de Souza Oliveira V, Tercio Guasti A, Cezario Dias MA, da Silva Dias C, Nascimento de Santana E, Tesch Kuhlcamp K, de Oliveira Arantes L, Machado Filho JA, Batista Queiroz R, Spaggiari Souza CA, Romais Schmildt E, Dousseau-Arantes S.   +12 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Benchmarking Machine Learning Algorithms for Microbial Electromethanogenesis: A Comprehensive Assessment with SHapley Additive exPlanation-Based Insights. [PDF]

ACS Sustain Chem Eng
Gadkari S, de Oliveira RS, Bolognesi S, Puig S, Nascimento EGS.   +4 more
europepmc   +1 more source