Results 111 to 120 of about 3,385,796 (302)
BuildingsUltra-high-performance concrete is widely used in bridge strengthening to improve mechanical performance and bridge durability. Interfacial bonding performance is a key factor in ensuring the effectiveness of ultra-high-performance concrete strengthening.
Chao Zhu +5 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Performance Optimization and Experimental Study of Small-Scale Potato-Grading Device
AgricultureTraditional potato grading in China relies mostly on manual sorting, which is labor-intensive, time-consuming, costly, and inefficient. To enhance the operational performance of potato-grading devices, this paper focuses on optimizing the slide rail ...
Haohao Zhao +3 more
doaj +1 more source
The Design and Performance of the MINERvA Detector
, 2005 The MINERvA experiment is designed to make precision measurements of various neutrino cross sections in the low energy regime. We describe the detector and give the performance of some of the measured quantities.Comment: 4 pages, 4 pages, 3 figures ...
Budd, H.
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Use of the optimal control model in the design of motion cue experiments [PDF]
An experiment is presented in which the effects of roll motions on human operator performance were investigated. The motion cues considered were the result of commanded vehicle motion and vehicle disturbances.
Junker, A. M., Levison, W. H.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Effect of Ramadan Intermittent Fasting on Cognitive Work Performance
Jurnal Teknik IndustriThis study aims to investigate the effect of Ramadan intermittent fasting on cognitive work performance using a more natural approach. To achieve the objective of this study, a natural experimental approach was employed by incorporating a pretest ...
Ridwan Aji Budi Prasetyo +2 more
doaj +1 more source
Estimator Selection: End-Performance Metric Aspects
, 2015 Recently, a framework for application-oriented optimal experiment design has been introduced. In this context, the distance of the estimated system from the true one is measured in terms of a particular end-performance metric.
Beck, Carolyn L. +2 more
core +1 more source