Results 81 to 90 of about 3,385,796 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Performance Experiment of R290/CO2 Cascade Refrigeration System

open access: yesZhileng xuebao, 2007
Performance experiments of R290/CO2 cascade refrigeration system were conducted. The performance of a cascade refrigeration system having a high temperature cycle using R290 as refrigerant and a CO2 based low temperature cycle was compared with that of a
宁静红, 李惠宇, 彭苗
doaj   +2 more sources

Study of the GEM detector performance in BM@N experiment

open access: yesEPJ Web of Conferences, 2018
BM@N is the fixed target experiment at the accelerator complex NICA-Nuclotron aimed to study nuclear matter in the relativistic heavy ion collisions.
Bazylev Sergei   +20 more
doaj   +1 more source

A Wind Tunnel Experimental Study on the Flexible Flapping Wing With an Attached Airfoil to the Root

open access: yesIEEE Access, 2019
With the purpose to improve the performance of the flexible membrane flapping wing, a kind of flapping wing with an attached airfoil to the root is designed and tested in a wind tunnel.
Peng Nian   +4 more
doaj   +1 more source

Skylab experiment performance evaluation manual [PDF]

open access: yes
A series of preparation analyses used for evaluating the performance of the Skylab corollary experiments under preflight, in-flight, and postflight conditions is given.
Meyers, J. E.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Implementation of the parallel mean shift-based image segmentation algorithm on a GPU cluster

open access: yesInternational Journal of Digital Earth, 2019
The mean shift image segmentation algorithm is very computation-intensive. To address the need to deal with a large number of remote sensing (RS) image segmentations in real-world applications, this study has investigated the parallelization of the mean ...
Fang Huang   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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