Results 131 to 140 of about 829,596 (216)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Advancing conversational diagnostic AI with multimodal reasoning. [PDF]

Nat Med
Saab K, Park C, Strother T, Freyberg J, Barrett DGT, Cheng Y, Weng WH, Stutz D, Tomasev N, Palepu A, Liévin V, Sharma Y, Ruparel R, Ahmed A, Vedadi E, Kanada K, Hughes C, Liu Y, Brown G, Gao Y, Li S, Mahdavi SS, Manyika J, Chou K, Matias Y, Hassidim A, Webster DR, Barral J, Eslami SMA, Kohli P, Rodman A, Natarajan V, Schaekermann M, Tu T, Karthikesalingam A, Tanno R.   +35 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Cognition and future depression: associations with risk in those with and without a history of depression. [PDF]

BMJ Ment Health
de Cates AN, Lee A, Winchester L, Ebmeier KP, Lalousis P, Upthegrove R, Murphy SE, Harmer CJ, Nichols T, Topiwala A.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Benchmarking GPT-5, LLaMA, and Mistral for Clinical Named Entity Recognition in Ophthalmology Progress Notes. [PDF]

Transl Vis Sci Technol
Majid I, Ruan FY, Wang SY.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Leveraging Large Language Models to Integrate Clinical Knowledge and Machine Learning Predictions for Lymph Node Metastasis Prediction: Development of a Knowledge-Augmented Framework. [PDF]

JMIR Med Inform
Yu H, Liu B, Zeng X, Ren M, Cao Z, Zhu X, Lu X, Xu J, Wu N, Hu D.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An interpretable ultrasound-based deep learning system for early breast cancer in a Chinese population. [PDF]

Insights Imaging
Wu S, Wang S, Liang D, Shi J, Shang X, Zhang L, Liu Y, Su X, Wang Y, Lu Q, Li Z, Zhao Z, Ji X, Li D, He Y.   +14 more
europepmc   +1 more source