Results 141 to 150 of about 19,582,157 (304)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Stonewall Union History document

open access: yes, 1988
History of the Stonewall Union, compiled internally. The history covers the founding of the organization, as well as significant court cases and actions it has taken part in from its founding to 1988.
Stonewall Columbus
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Validating an early pregnancy HbA1c as the screening test for gestational diabetes mellitus: findings from PRISMA Pakistan cohort. [PDF]

open access: yesBMJ Open
Naz S   +8 more
europepmc   +1 more source

Choreographing Histories of the Art of performance. Moments. A history of Performance in 10 acts

open access: yesVisualidades, 2015
Numerosas exposições têm sido recentemente organizadas em torno de um encontro da performance e da dança contemporânea. As instituições tradicionalmente dedicadas às artes visuais abrem-se a performance, ao mesmo tempo que a dança. Os coreógrafos cada vez mais numerosos preferem as galerias dos museus e dos centros de exposição que a sala de espetáculo
openaire   +1 more source

History matters, but how? An example of Ottoman and Habsburg legacies and judicial performance in Romania [PDF]

open access: yes
The paper examines the interdependence of historical legacies and current contextual factors as determinants of economic and political performance. It shows that behavioral patterns based on identical legacies could lead to very different (if not the ...
Mendelski, Martin, Libman, Alexander
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy