Results 91 to 100 of about 13,518,769 (291)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ensuring the Efficiency and Effectiveness of Joint Clinical Assessment in National HTA Decision-Making: Insights from the 2024 CIRS Multi-Stakeholder Workshop

Journal of Market Access & Health Policy
Background: This study explored the readiness and strategic considerations of companies and key stakeholders for the implementation of the Joint Clinical Assessment (JCA) under the European Health Technology Assessment Regulation (HTAR).
Ting Wang, Neil McAuslane
doaj   +1 more source

What are the important technologies for bin picking? Technology analysis of robots in competitions based on a set of performance metrics

Adv. Robotics, 2019
Bin picking is still a challenge in robotics, as patent in recent robot competitions. These competitions are an excellent platform for technology comparisons since some participants may use state-of-the-art technologies, while others may use conventional
M. Fujita, Y. Domae, A. Noda, G. A. G. Ricardez, T. Nagatani, Andy Zeng, Shuran Song, Alberto Rodriguez, A. Causo, I. Chen, T. Ogasawara   +10 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

On Complexity, Energy- and Implementation-Efficiency of Channel Decoders

, 2010
Future wireless communication systems require efficient and flexible baseband receivers. Meaningful efficiency metrics are key for design space exploration to quantify the algorithmic and the implementation complexity of a receiver.
Kienle, Frank, Meyr, Heinrich, Wehn, Norbert   +2 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

On the analytical study of the service quality of Indian Railways under soft-computing paradigm

Transport
Indian Railway Catering and Tourism Corporation (IRCTC) is among the busiest railways reservation systems since the Indian Railways (IR) is the vital and economical mode of transportation in India. Hence, rating of the trains seems to be critical aspect
Saibal Majumder, Aarti Singh, Anupama Singh, Mykola Karpenko, Haresh Kumar Sharma, Somnath Mukhopadhyay   +5 more
doaj   +1 more source

Why We Need New Evaluation Metrics for NLG

, 2017
The majority of NLG evaluation relies on automatic metrics, such as BLEU . In this paper, we motivate the need for novel, system- and data-independent automatic evaluation methods: We investigate a wide range of metrics, including state-of-the-art word ...
Curry, Amanda Cercas, Dušek, Ondřej, Novikova, Jekaterina, Rieser, Verena   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source