Results 61 to 70 of about 63,694 (309)
Sensemaking reconsidered : towards a broader understanding through phenomenology [PDF]
, 2020 We develop a typology of sensemaking in organizations that reconsiders existing sensemaking research by providing a more coherent and integrative conceptualization of what defines sensemaking and how it is connected with organizing.
Sandberg, Jörgen, Tsoukas, Haridimos
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
(Big) Data, Diagram Aesthetics and the Question concerning Beauty
MedieKultur: Journal of Media and Communication Research, 2016 The article investigates whether and in which way artistic artefacts deploying big data can be experienced as beautiful. The question is relevant, because the sentiment of beauty indicates besides an immediate sensory valuation also changes in cultural ...
Falk Heinrich
doaj +1 more source
A Machine Made of Words: Our Incompletely Theorized Constitution [PDF]
, 2011 [Excerpt]”Many scholars have observed that the Constitution of the United States can be understood as an example of what Cass Sunstein calls an “incompletely theorized agreement.” The Constitution contains a number of extremely general terms, such as ...
Brazeal, Gregory
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Nouveaux Cahiers de MargeCet article propose d’examiner la conception d’un dispositif de recherche performative prenant l’imaginaire cyborg comme question de recherche et interrogeant, à partir d’un agencement interdisciplinaire convoquant robotique embarquée ...
Syd Reynal, Clémence Martel
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Przegląd KulturoznawczyVideo synthesis is a method of producing images using a video synthesizer that can generate images without any external input, such as a camera.
Małgorzata Dancewicz-Pawlik
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Media do not exist : performativity and mediating conjunctures [PDF]
, 2019 Collection : Theory on demand ; 31Media Do Not Exist: Performativity and Mediating Conjunctures by Jean-Marc Larrue and Marcello Vitali-Rosati offers a radically new approach to the phenomenon of mediation, proposing a new understanding that challenges ...
Larrue, Jean-Marc +1 more
core