Results 71 to 80 of about 63,694 (309)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

SenCity Workshop: Sensing Festivals as Cities [PDF]

open access: yes, 2013
ACM allows authors to post the accepted, peer-reviewed version of their paper on the institutional repository. The published version is available at .In order to sense the mood of a city, we propose first looking at festivals.
JARVIS, MD, UbiComp
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Meyerhold Bound: Montažstroj's “Vatrotehna (2.0)” and the Barbaric Discipline of the Machine

open access: yesColloquia Humanistica, 2017
Meyerhold bBound: Montažstroj's Vatrotehna (2.0) and the Barbaric Discipline of the Machine The paper deals with Montažstroj’s two versions of Vatrotehna performance, inspired by Aeschylus’ Prometheus Bound and Meyerhold’s tragic execution.
Leo Rafolt
doaj   +1 more source

Emotional Biosensing: Exploring Critical Alternatives [PDF]

open access: yes, 2018
Emotional biosensing is rising in daily life: Data and categories claim to know how people feel and suggest what they should do about it, while CSCW explores new biosensing possibilities.
Chuang, John   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Machines for Communication New Media and New Theatre in Avant-Garde Conceptions

open access: yesPamiętnik Teatralny
The Avant-Garde art of the beginning of the twentieth century had its nascence alongside that of the mass media. The parallelism of the languages of these two phenomena is also important for the modern perception of performativity, which has been ...
Paweł Stangret
doaj   +1 more source

How to translate artificial intelligence? Myths and justifications in public discourse

open access: yesBig Data & Society, 2020
Automated technologies populating today’s online world rely on social expectations about how “smart” they appear to be. Algorithmic processing, as well as bias and missteps in the course of their development, all come to shape a cultural realm that in ...
Jonathan Roberge   +2 more
doaj   +1 more source

Don’t throw rocks from the side-lines: A sociomaterial exploration of organizational blogs as boundary objects [PDF]

open access: yes, 2017
Purpose Social media such as blogs are being widely used in organizations in order to undertake internal communication and share knowledge, rendering them important boundary objects.
Daniel, Elizabeth   +2 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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