Results 31 to 40 of about 907,151 (342)

Regulatory effects of blood constituents on the function and metabolism of the cat brain in perfusion ezperiments. Brain perfusion with artificial blood containing low molecular dextran and amino acids [PDF]

, 1967
As a link in a series of studies on the effects of blood constituents on the brain function by means of brain perfusion, we used four kinds of artificial blood; namely, the blood containing a low molecular dextran, one containing glutamic acid, one ...
Edamatsu, Kazuyasu, Morimitsu, Junsuke, Nakashima, Yoshihiko, Okumura, Nikichi, Otsuki, Saburo, Watanabe, Shosuke   +5 more
core   +1 more source

Novel portable hypothermic machine perfusion preservation device enhances cardiac viability of donated human hearts

Frontiers in Cardiovascular Medicine
IntroductionHeart transplant remains the gold standard treatment for patients with advanced heart failure. However, the list of patients waiting for a heart transplant continues to increase.
Kristina Andrijauskaite, Rafael J. Veraza, Riley P. Lopez, Zach Maxwell, Isabella Cano, Exal E. Cisneros, Israel J. Jessop, Maria Basurto, George Lamberson, Michelle D. Watt, Joseph Nespral, Masahiro Ono, Leonid Bunegin   +12 more
doaj   +1 more source

Do continuous forms of intra-operative ultrafiltration enhance recovery after adult cardiac surgery with cardiopulmonary bypass? A protocol for systematic review and meta-analysis of randomized controlled trials

Systematic Reviews, 2021
Background Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a systemic inflammatory syndrome that adversely impacts cardiopulmonary function and can contribute to prolonged postoperative recovery.
Joel Bierer, David Horne, Roger Stanzel, Mark Henderson, Leah Boulos, Jill Hayden   +5 more
doaj   +1 more source

A novel strategy for conversion from pediatric V-A ECMO to CPB circuit

The Journal of ExtraCorporeal Technology
This article describes two novel strategies to convert a veno-arterial extracorporeal membrane oxygenator (V-A ECMO) supported pediatric patient circuit to a cardiopulmonary bypass (CPB) circuit.
Lal Amita, Machin David, Lansdowne William   +2 more
doaj   +1 more source

Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection [PDF]

, 2009
Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against ...
Aldakkak, Mohammed, Camara, Amadou K.S., Chen, Qun, Heisner, James S., Lesnefsky, Edward J., Stowe, David F.   +5 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Adapting and applying student-centered learning in a perfusion clinical rotation

The Journal of ExtraCorporeal Technology
While the process of teaching student perfusionists has been in development since the 1950s, the publication of the processes to improve perfusion clinical education has been largely lacking.
Neal James R., Blau Caitlin, Colby Clint
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Novel inflammatory mediator profile observed during pediatric heart surgery with cardiopulmonary bypass and continuous ultrafiltration

Journal of Translational Medicine, 2023
Background Cardiopulmonary bypass (CPB) is associated with systemic inflammation, featuring increased levels of circulating pro-inflammatory cytokines.
Joel Bierer, Roger Stanzel, Mark Henderson, Suvro Sett, John Sapp, Pantelis Andreou, Jean S. Marshall, David Horne   +7 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source