Results 61 to 70 of about 2,545,303 (281)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial

Dentistry Journal
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of ...
Georgios Kardaras, Ruxandra Christodorescu, Marius Boariu, Darian Rusu, Alla Belova, Salvatore Chinnici, Octavia Vela, Viorelia Radulescu, Simina Boia, Stefan-Ioan Stratul   +9 more
doaj   +1 more source

A Retrospective Analysis of Biological Complications of Dental Implants

International Journal of Dentistry, 2022
Background and Objective. Several risk factors have been implicated in onset and development of peri-implant diseases. The impact of these factors, however, remains controversial across the different clinical settings and populations.
Momen A. Atieh, Zainab Almutairi, Fatemeh Amir-Rad, Mohammed Koleilat, Andrew Tawse-Smith, Sunyoung Ma, Lifeng Lin, Nabeel H. M. Alsabeeha   +7 more
doaj   +1 more source

In Vitro Anti-Biofilm and Antibacterial Properties of Streptococcus downii sp. nov.

Microorganisms, 2021
The aim of this study was to evaluate the potential anti-biofilm and antibacterial activities of Streptococcus downii sp. nov. To test anti-biofilm properties, Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum ...
Maigualida Cuenca, María Carmen Sánchez, Pedro Diz, Lucía Martínez-Lamas, Maximiliano Álvarez, Jacobo Limeres, Mariano Sanz, David Herrera   +7 more
doaj   +1 more source

New strategies and developments for peri-implant disease [PDF]

Brazilian Oral Research, 2019
The aim of this illustrated review is to present the new strategies and developments to treatment and diagnosis of periimplant diseases. Periimplant disease is a subject of great concern for modern dentistry. The numbers of implant exhibiting biological complications grows as implant dentistry expands thought-out the world.
Arthur Belém NOVAES JUNIOR, Umberto Demoner RAMOS, Mariana de Sousa RABELO, Gabriel Bastos FIGUEREDO   +3 more
openaire   +5 more sources

Mucosite peri-implantar: qual o melhor tratamento? [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Objetivo: Avaliar a melhor terapia para o tratamento da mucosite periimplantar. Metodologia: Foram avaliados 64 implantes com mucosite periimplantar.
Ouriques, Felipe Damerau
core  

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

The referral pattern and treatment modality for peri-implant disease between periodontists and non-periodontist dentists

BMC Oral Health, 2023
Objectives This study is to investigate the referral pattern and treatment modality of dentists in the management of peri-implant diseases between periodontists and non-periodontist dentists (NPDs).
Chia-Dan Cheng, Yi-Wen Cathy Tsai, Wan-Chien Cheng, Fu-Gong Lin, Pei-Wei Weng, Ying-Wu Chen, Ren-Yeong Huang, Wei-Liang Chen, Yi-Shing Shieh, Cheng-En Sung   +9 more
doaj   +1 more source