Results 171 to 180 of about 114,000 (325)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Body Mass Index and Its Influence on Electrocardiographic Parameters in Healthy and Cardiovascular Patients

open access: yesObesity Science &Practice, Volume 11, Issue 6, December 2025.
ABSTRACT Objective Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide. Smoking, unhealthy diets, physical inactivity, and psychological stress are the main lifestyle factors associated with CVDs. This study was designed to investigate the relationship between electrocardiographic (ECG) changes and various body mass index (BMI)
Roholla Hemmati   +5 more
wiley   +1 more source

Post‐Transplant Cyclophosphamide for Graft‐Versus‐Host Disease Prophylaxis in Pediatric Stem Cell Transplantation

open access: yesPediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT Graft‐Versus‐Host disease (GVHD) is a leading contributor to morbidity and mortality following stem cell transplantation (SCT). Current GVHD prevention methods utilize a combination of immunosuppressive drugs to prevent injury to host tissues.
Aaron E. Fan   +6 more
wiley   +1 more source

Constrictive pericarditis presenting as chylothorax [PDF]

open access: yes, 2011
Chylothorax is a rare clinical condition that can be attributed to a damaged thoracic duct. The condition is suggested by aspiration of milky white fluid from the pleural cavity and is commonly associated with either malignant diseases or trauma (e.g ...
Fatimi, Saulat H.   +4 more
core  

Antimicrobial prescribing guidelines for horses in Australia

open access: yesAustralian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt   +18 more
wiley   +1 more source

Mycoplasma pneumonia : an unusual cause of acute myocarditis in childhood [PDF]

open access: yes, 2006
Mycoplasma pneumoniae is primarily a respiratory pathogen but may affect exhibit a diverse range of presentations from asymptomatic infection to life threatening conditions. Myocarditis of varying severity is an unusual complication.
Bailey, Mark   +4 more
core  

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

open access: yes, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark   +2 more
core  

Rapid Corticosteroid Withdrawal After Cardiac Transplantation Improves Outcomes

open access: yesClinical Transplantation, Volume 39, Issue 12, December 2025.
ABSTRACT Background Modern immunosuppressive regimens have been associated with lower rejection rates after heart transplantation (HTx), yet long‐term outcomes have remained limited by drug‐related complications. Since 2010, our program has implemented a protocolized corticosteroid withdrawal (CSW) strategy following induction with rabbit anti ...
Claudia Minato   +10 more
wiley   +1 more source

Colchicine and cardiovascular events: An updated meta‐analysis of published randomized controlled trials

open access: yesJournal of Internal Medicine, Volume 298, Issue 6, Page 711-717, December 2025.
Abstract Background Colchicine shows promise in reducing cardiovascular risk, but a recent study raised the question whether this is really the case. We conducted a meta‐analysis of randomized controlled trials (RCTs) to assess its impact on cardiovascular outcomes in secondary prevention.
Sining Xie   +4 more
wiley   +1 more source

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