Results 1 to 10 of about 50,572 (275)
Some of the next articles are maybe not open access.
Joint Bone Spine, 2006
Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in colchicine pharmacokinetics: the colchicine receptor, tubulin, which governs the plasma elimination half-life of the drug; intestinal and hepatic CYP3A4, which is key to
Elisabeth, Niel, Jean-Michel, Scherrmann
exaly +3 more sources
Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in colchicine pharmacokinetics: the colchicine receptor, tubulin, which governs the plasma elimination half-life of the drug; intestinal and hepatic CYP3A4, which is key to
Elisabeth, Niel, Jean-Michel, Scherrmann
exaly +3 more sources
Journal of the American Academy of Dermatology, 1998
Colchicine is a medication most often used to treat symptoms of gout. This drug has also been shown to have beneficial effects on cutaneous conditions, including leukocytoclastic vasculitis, psoriasis, and Sweet's syndrome. Colchicine inhibits the function of polymorphonuclear leukocytes, and dermatoses with a strong presence of these cells may benefit
T P, Sullivan, L E, King, A S, Boyd
openaire +2 more sources
Colchicine is a medication most often used to treat symptoms of gout. This drug has also been shown to have beneficial effects on cutaneous conditions, including leukocytoclastic vasculitis, psoriasis, and Sweet's syndrome. Colchicine inhibits the function of polymorphonuclear leukocytes, and dermatoses with a strong presence of these cells may benefit
T P, Sullivan, L E, King, A S, Boyd
openaire +2 more sources
Scandinavian Journal of Rheumatology, 1996
Colchicine myopathy typically presents as painless muscle weakness. This report describes a post renal-transplant patient who presented with pain in both extremities bilaterally that was refractory to narcotic analgesics. He had been on low dose daily colchicine for 7 years. Laboratory, EMG, and biopsy findings all supported the diagnosis of colchicine
openaire +2 more sources
Colchicine myopathy typically presents as painless muscle weakness. This report describes a post renal-transplant patient who presented with pain in both extremities bilaterally that was refractory to narcotic analgesics. He had been on low dose daily colchicine for 7 years. Laboratory, EMG, and biopsy findings all supported the diagnosis of colchicine
openaire +2 more sources
Annals of the New York Academy of Sciences, 2009
Purified from a Mediterranean plant nearly two centuries ago, colchicine has been discovered to inhibit many steps in the inflammatory process. The drug has good oral bioavailability and some enterohepatic recirculation, requiring dose adjustments for kidney disease and avoidance in liver disease. Toxicities are primarily gastrointestinal, hepatic, and
Anupama, Bhat +3 more
openaire +2 more sources
Purified from a Mediterranean plant nearly two centuries ago, colchicine has been discovered to inhibit many steps in the inflammatory process. The drug has good oral bioavailability and some enterohepatic recirculation, requiring dose adjustments for kidney disease and avoidance in liver disease. Toxicities are primarily gastrointestinal, hepatic, and
Anupama, Bhat +3 more
openaire +2 more sources
The Journal of Emergency Medicine, 1994
Colchicine poisoning is an unusual but serious form of drug intoxication. Although relatively uncommon, colchicine poisoning may produce life-threatening systemic effects that must be recognized and treated by the emergency physician. This alkaloid found in Colchicum autumnale is used primarily in the treatment of gout.
openaire +2 more sources
Colchicine poisoning is an unusual but serious form of drug intoxication. Although relatively uncommon, colchicine poisoning may produce life-threatening systemic effects that must be recognized and treated by the emergency physician. This alkaloid found in Colchicum autumnale is used primarily in the treatment of gout.
openaire +2 more sources
JCR: Journal of Clinical Rheumatology, 1996
Colchicine myopathy can complicate standard treatment of gout, especially in those patients with underlying renal insufficiency. The symptoms of this disorder are frequently insidious, and the diagnostic tests used in its evaluation are mostly nonspecific.
D S, Uri, M, Biavis
openaire +2 more sources
Colchicine myopathy can complicate standard treatment of gout, especially in those patients with underlying renal insufficiency. The symptoms of this disorder are frequently insidious, and the diagnostic tests used in its evaluation are mostly nonspecific.
D S, Uri, M, Biavis
openaire +2 more sources
Trends in Cardiovascular Medicine, 2015
Colchicine is one of the oldest available drugs. It has been used for centuries to treat and prevent gouty attacks and more recently to prevent attacks of autoinflammatory diseases such as Familial Mediterranean Fever. Its main mechanism of action is the capability to block the polymerization of tubulin, thus affecting the function of microtubules. The
openaire +3 more sources
Colchicine is one of the oldest available drugs. It has been used for centuries to treat and prevent gouty attacks and more recently to prevent attacks of autoinflammatory diseases such as Familial Mediterranean Fever. Its main mechanism of action is the capability to block the polymerization of tubulin, thus affecting the function of microtubules. The
openaire +3 more sources