Results 1 to 10 of about 57,858 (265)
Modeling of colchicine biotransformation by COVID-19 associated Klebsiella pneumoniae: synergistic effects of cell adaptation and gamma irradiation [PDF]
BMC Pharmacology and ToxicologyBackground Microbial biotransformation strategies for prescribed drugs have attracted great interest because the biotransformation process simulates what happens in the human metabolism and may be considered a resource for new pharmaceuticals.
Walaa S. Hendawy +2 more
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Frontiers in Pharmacology, 2021 Background: The beneficial effects of colchicine on cardiovascular disease have been widely reported in recent studies. Previous research demonstrated that colchicine has a certain protective effect on ischemic myocardium and has the potential to treat ...
Yuanjun Tang +8 more
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Effect of Colchicine on Secondary Acute Lung Injury in an Experimental Sepsis Model in Rats
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023 Introduction: An irregular systemic inflammatory response in sepsis can induce acute lung injury (ALI), which is characterized by the exaggerated inflammation of the lung tissue.
Mehmet CEYLAN +4 more
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Inhibition of the Glycine Receptor alpha 3 Function by Colchicine
Frontiers in Pharmacology, 2020 Colchicine is a plant alkaloid that is widely used as a therapeutic agent. It is widely accepted that colchicine reduces the production of inflammatory mediators mainly by altering cytoskeleton dynamics due to its microtubule polymerization inhibitory ...
Carola Muñoz-Montesino +11 more
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Frontiers in Cardiovascular Medicine, 2022 BackgroundThis study investigated the effect of colchicine use on the risks of heart disease (HD), pericarditis, endocarditis, myocarditis, cardiomyopathy, cardiac arrhythmia, and cardiac failure in patients having interstitial lung disease (ILD) with ...
Jun-Jun Yeh +11 more
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International Journal of Cardiology: Heart & Vasculature, 2023 Background: Colchicine has anti-inflammatory properties, but its utility in improving cardiovascular outcomes has been disputed. Here, we study the impact of colchicine on cardiovascular outcomes in patients with gout with and without coronary artery ...
Muhammad U. Siddiqui +5 more
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Frontiers in Pharmacology, 2019 Objectives: A previous study suggested that colchicine may cause leukopenia and increase the risk of infection, such as pneumonia. Thus, we investigated the potential relationship between colchicine use and risk of developing pneumonia.Methods: Data were
Tsung-Lin Tsai +8 more
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Colchicine Impacts Leukocyte Trafficking in Atherosclerosis and Reduces Vascular Inflammation
Frontiers in Immunology, 2022 BackgroundInflammation strongly contributes to atherosclerosis initiation and progression. Consequently, recent clinical trials pharmacologically targeted vascular inflammation to decrease the incidence of atherosclerosis-related complications ...
Ulrike Meyer-Lindemann +23 more
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Colchicine reduces atherosclerotic plaque vulnerability in rabbits
Atherosclerosis Plus, 2021 Background and aims: The anti-inflammatory agent colchicine is gaining interest as a treatment for coronary artery disease. However, the effects of colchicine in atherosclerotic animal models are mostly unknown. This study aimed to evaluate colchicine in
François Roubille +12 more
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High colchicine doses are more effective in COVID-19 outpatients than nirmatrelvir/ritonavir, remdesivir, and molnupiravir [PDF]
PharmaciaColchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, and cardioprotective effects, as well as its role in preventing microvascular thrombosis.
Vanyo Mitev +11 more
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