Results 41 to 50 of about 50,572 (275)

Clinically acceptable colchicine concentrations have potential for the palliative treatment of human cholangiocarcinoma

Kaohsiung Journal of Medical Sciences, 2015
Microtubules are an ideal target for anticancer drugs because of their essential role in mitosis. Colchicine is a microtubule destabilizer. Whether the clinically acceptable colchicine concentrations had anticancer effects on human cholangiocarcinoma ...
Chun-Chieh Wu, Zu-Yau Lin, Chao-Hung Kuoc, Wan-Long Chuang   +3 more
doaj   +1 more source

Pengaruh Manipulasi Ploidi Terhadap Efektivitas Pertumbuhan dan Hasil Tanaman Labu Kuning (Cucurbita moschene Dutchene)

Rekayasa, 2023
Pumpkin (Cucurbita moschene Duthene) is plant sources of food that has high nutrition content. Increasing the productivity of pumpkin can be done through programs, which is the ploidy manipulation technique, the technique using a mutagen, namely ...
Reza Prakoso Dwi Julianto, I Made Indra Agastya, Wahyu Fikrinda   +2 more
doaj   +1 more source

Colchicine in overdose [PDF]

British Journal of General Practice, 2017
We read with interest the letter from Lloyd warning of the danger of colchicine overdose1 and agree that this can have devastating consequences. However, the …
Edward, Roddy, Christian D, Mallen
openaire   +2 more sources

An open-label continuation trial of tocilizumab for familial Mediterranean fever with colchicine ineffective or intolerance

, 2020
Background:Colchicine is the first-line treatment for familial Mediterranean fever (FMF), but secondary amyloidosis resulting from persistent inflammation is a concern in patients with colchicine-resistant or colchicine-intolerant FMF.
Fukushima, Chizu, Kawakami, Atsushi, Chizu Fukushima, Hiroshi Yamamoto, Hosogaya, Naoki, Yamamoto, Hiroshi, Sato, Shuntaro, Koga, Tomohiro, Shuntaro Sato, Shinpei Morimoto, Atsushi Kawakami, Hagimori, Naoko, Morimoto, Shinpei, Naoki Hosogaya, Tomohiro Koga, Naoko Hagimori   +15 more
core   +1 more source

Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway

Bangladesh Journal of Pharmacology, 2023
The role of cell morphological changes in colchicine-inhibited tubulin polymerization of rabbit articular chondrocytes and their involvement in dedifferentiation were investigated.
Yohan Han, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim   +3 more
doaj   +1 more source

The etiology and autopsy findings in Colchicine intoxication-related deaths

Medicine Science, 2016
Colchicine is a drug which has a very narrow therapeutic range. This drug has been commonly used for Familial Mediterranean Fever (FMF), Behcet’s disease, gout arthritis and acute pseudo gout attacks.
Servet Birgin Iritas, Ahmet Hakan Dinc, Baris Akduman, Bora Ozdemir, Ceylan Bal, Hacer Y. Teke, Mehtap Ozdemir, Bulent Degirmenci   +7 more
doaj   +1 more source

Accompanying autoimmune diseases may have a role in colchicine resistance in adult familial mediterranean fever patients

Medicine Science
Colchicine is the primary treatment for familial Mediterranean fever (FMF); however, colchicine resistance poses a major challenge, affecting about 5–10% of patients.
Ozlem Kilic, Emre Tekgoz, Seda Colak, Mehmet Nur Kaya, Muhammet Cinar, Sedat Yilmaz   +5 more
doaj   +1 more source

Transcriptome analysis reveals plant response to colchicine treatment during on chromosome doubling

Scientific Reports, 2017
Colchicine was commonly used to artificially double chromosomes while the transcriptome changes in colchicine treated plants has rarely been characterized.
Kai Zhou, Paige Fleet, Eviatar Nevo, Xinquan Zhang, Genlou Sun   +4 more
doaj   +1 more source

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda, Ambarish Kunwar   +3 more
doaj   +1 more source

Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout

Scientific Reports, 2022
This study aimed to determine the effect of colchicine use on the risk of stroke among patients with diabetes mellitus (DM). We retrospectively enrolled patients with DM between 2000 and 2013 from the Longitudinal Health Insurance Database and divided ...
Jun-Jun Yeh, I-Ling Kuo, Hei-Tung Yip, Min-Yuan Hsueh, Chung-Y. Hsu, Chia-Hung Kao   +5 more
doaj   +1 more source