Results 21 to 30 of about 39,902 (221)

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

PLoS ONE, 2019
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses.
Harutyun Sahakyan, Narek Abelyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan   +4 more
doaj   +1 more source

Biorhizome: A Biosynthetic Platform for Colchicine Biomanufacturing

Frontiers in Plant Science, 2017
Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba.
Ganapathy Sivakumar, Kamran Alba, Gregory C. Phillips   +2 more
doaj   +1 more source

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

Biosynthesis of Colchicine [PDF]

Nature, 1960
OF several proposals1–4 concerning the biogenesis of the alkaloid colchicine (5; R 1 = R 2 = Me), only that of Wenkert4 involves the intervention of an intact tropolone ring prior to formation of ring B.
openaire   +2 more sources

Successfully Treated Severe Colchicine Intoxication in an Adolescent

Türk Yoğun Bakim Derneği Dergisi, 2022
The contain is extracted from the autumn crocus plant, colchicine that an anti-inflammatory drug. The use of colchicine impairs mobilization and activation of neutrophil and supporting treating from some rheumatological diseases especially in childhood ...
Hatice Feray Arı, Berna Kırhan, Murat Arı   +2 more
doaj   +1 more source

Clinically acceptable colchicine concentrations have potential for the palliative treatment of human cholangiocarcinoma

Kaohsiung Journal of Medical Sciences, 2015
Microtubules are an ideal target for anticancer drugs because of their essential role in mitosis. Colchicine is a microtubule destabilizer. Whether the clinically acceptable colchicine concentrations had anticancer effects on human cholangiocarcinoma ...
Chun-Chieh Wu, Zu-Yau Lin, Chao-Hung Kuoc, Wan-Long Chuang   +3 more
doaj   +1 more source

Effect of Treatment with Colchicine after Acute Coronary Syndrome on Major Cardiovascular Events: A Systematic Review and Meta-Analysis of Clinical Trials

Cardiovascular Therapeutics, 2022
Aim. Colchicine as an anti-inflammatory drug might be effective in the treatment of atherosclerosis, an inflammatory-based condition. The aim of this systematic review and meta-analysis was to evaluate the impact of colchicine on acute coronary syndrome (
Erfan Razavi, Akam Ramezani, Asma Kazemi, Armin Attar   +3 more
doaj   +1 more source

Reducing length of hospital stay with colchicine

Journal of Infection in Developing Countries, 2022
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions.
Özlem Karakaş, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, İhsan Ateş, Ahmet Omma, Orhan Küçüksahin   +10 more
doaj   +1 more source

Colchicine in overdose [PDF]

British Journal of General Practice, 2017
We read with interest the letter from Lloyd warning of the danger of colchicine overdose1 and agree that this can have devastating consequences. However, the …
Edward, Roddy, Christian D, Mallen
openaire   +2 more sources

Accompanying autoimmune diseases may have a role in colchicine resistance in adult familial mediterranean fever patients

Medicine Science
Colchicine is the primary treatment for familial Mediterranean fever (FMF); however, colchicine resistance poses a major challenge, affecting about 5–10% of patients.
Ozlem Kilic, Emre Tekgoz, Seda Colak, Mehmet Nur Kaya, Muhammet Cinar, Sedat Yilmaz   +5 more
doaj   +1 more source