Results 31 to 40 of about 78,062 (255)

The etiology and autopsy findings in Colchicine intoxication-related deaths

Medicine Science, 2016
Colchicine is a drug which has a very narrow therapeutic range. This drug has been commonly used for Familial Mediterranean Fever (FMF), Behcet’s disease, gout arthritis and acute pseudo gout attacks.
Servet Birgin Iritas, Ahmet Hakan Dinc, Baris Akduman, Bora Ozdemir, Ceylan Bal, Hacer Y. Teke, Mehtap Ozdemir, Bulent Degirmenci   +7 more
doaj   +1 more source

Genotoxic mixtures and dissimilar action: Concepts for prediction and assessment [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the creative commons Attribution license which permits any use, distribution, and reproduction in any medium, provided ...
A Bouslimi, A Elhajouji, Andreas Kortenkamp, AY Kocaman, CI Bliss, D Kirkland, E Hecker, K Drescher, K Hashimoto, K Hashimoto, M Faust, M Fenech, M Honma, M Marinovich, M Scholze, Martin Scholze, MC Berenbaum, MC Berenbaum, National Research Council, P Fowler, R Altenburger, S Ermler, S Loewe, Sibylle Ermler, T Backhaus, T Mosmann, W Slob, WK Lutz, WK Lutz, WK Lutz   +29 more
core   +2 more sources

Accompanying autoimmune diseases may have a role in colchicine resistance in adult familial mediterranean fever patients

Medicine Science
Colchicine is the primary treatment for familial Mediterranean fever (FMF); however, colchicine resistance poses a major challenge, affecting about 5–10% of patients.
Ozlem Kilic, Emre Tekgoz, Seda Colak, Mehmet Nur Kaya, Muhammet Cinar, Sedat Yilmaz   +5 more
doaj   +1 more source

Transcriptome analysis reveals plant response to colchicine treatment during on chromosome doubling

Scientific Reports, 2017
Colchicine was commonly used to artificially double chromosomes while the transcriptome changes in colchicine treated plants has rarely been characterized.
Kai Zhou, Paige Fleet, Eviatar Nevo, Xinquan Zhang, Genlou Sun   +4 more
doaj   +1 more source

Successfully Treated Severe Colchicine Intoxication in an Adolescent

Türk Yoğun Bakim Derneği Dergisi, 2022
The contain is extracted from the autumn crocus plant, colchicine that an anti-inflammatory drug. The use of colchicine impairs mobilization and activation of neutrophil and supporting treating from some rheumatological diseases especially in childhood ...
Hatice Feray Arı, Berna Kırhan, Murat Arı   +2 more
doaj   +1 more source

Destabilising microtubule polymerization regulates chondrocyte dedifferentiation and inflammation via nuclear factor kappa b and β-catenin pathway

Bangladesh Journal of Pharmacology, 2023
The role of cell morphological changes in colchicine-inhibited tubulin polymerization of rabbit articular chondrocytes and their involvement in dedifferentiation were investigated.
Yohan Han, Young Seok Eom, Fahad Hassan Shah, Song Ja Kim   +3 more
doaj   +1 more source

Colchicine-induced myoneuropathy in a cyclosporine-treated renal transplant recipient

Kidney Research and Clinical Practice, 2013
Colchicine is a relatively safe medication that is widely used for both prevention and treatment of gout attack. However, serious adverse events, including myoneuropathy and multiorgan failure, have been reported.
Kyungmin Huh, Ji Young Joung, Hyemin Jeong, Dongmo Je, Yoon Young Cho, Hye Ryoun Jang, Wooseong Huh   +6 more
doaj   +1 more source

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda, Ambarish Kunwar   +3 more
doaj   +1 more source

Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism

Future Science OA, 2021
Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice.
Fabien Huet, Jérémy Fauconnier, Marion Legall, Pierre Sicard, Catherine Lozza, Alain Lacampagne, François Roubille   +6 more
doaj   +1 more source

The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]

, 1964
1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
core   +1 more source