Results 31 to 40 of about 50,572 (275)

Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo [PDF]

, 2004
In gene therapy, a clinically relevant therapeutic effect requires long-term expression of the desired gene at a level sufficient to correct or at least alleviate the underlying gene defect.
Pfützner, Wolfgang, Vogel, Jonathan C.
core   +1 more source

High colchicine doses are more effective in COVID-19 outpatients than nirmatrelvir/ritonavir, remdesivir, and molnupiravir [PDF]

Pharmacia
Colchicine has an excellent basis for being effective against COVID-19 due to its anti-inflammatory, immunomodulatory, and cardioprotective effects, as well as its role in preventing microvascular thrombosis.
Vanyo Mitev, Krasimir Marinov, Rumen Tiholov, Konstantin Tachkov, Radoslav Bilyukov, Aleksander I. Lilov, Kiril R. Palaveev, Ani Miteva, Iva Miteva, Violeta S. Dimitrova, Nikolay Ishkitiev, Tsanko Mondeshki   +11 more
doaj   +3 more sources

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support

Frontiers in Pediatrics, 2021
Colchicine poisoning is associated with a poor prognosis, especially when leading to shock and multi-organ failure, and management is limited to supportive care, including multiple-dose activated charcoal.
Maria Pérez Marín, Sylvain Prod'hom, Suzanne Francesca de Villiers, Thomas Ferry, Vivianne Amiet, Julia Natterer, Maria-Helena Perez, Thierry Buclin, Haithem Chtioui, David Longchamp   +9 more
doaj   +1 more source

COLCHICINE [PDF]

The Journal of Nervous and Mental Disease, 1876
n ...
openaire   +2 more sources

Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines

Kaohsiung Journal of Medical Sciences, 2016
Colchicine is a very cheap microtubule destabilizer. Because microtubules are an ideal target for anticancer drugs, the purpose of this study was to investigate whether clinically acceptable colchicine concentrations have anticancer effects on gastric ...
Zu-Yau Lin, Chao-Hung Kuo, Deng-Chyang Wu, Wan-Long Chuang   +3 more
doaj   +1 more source

Comparison of Different Pharmaceutical Preparations of Colchicine in Children with Familial Mediterranean Fever: Is Colchicine Opocalcium a Good Alternative?

, 2021
Background: Colchicine is an anti-inflammatory agent used for preventing familial Mediterranean fever (FMF) attacks and amyloidosis.
Selçuk Yüksel, Unsal, Erbil, Serkan Türkuçar, Makay, BALAHAN, Acari, Ceyhun, Balahan Makay, Yukser, Selcuk, Yuksel, Selcuk, Ceyhun Acari, Gülçin Otar Yener, Erbil Ünsal, Turkucar, Serkan, Yener, Gulcin Otar, Hatice Adıgüzel Dundar, Dundar, Hatice Adiguzel   +14 more
core   +1 more source

Comparison of the efficacy and safety of tocilizumab for colchicine-resistant or colchicine-intolerant familial Mediterranean fever: study protocol for an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial [PDF]

, 2018
Background: Familial Mediterranean fever (FMF) is an inherited disorder caused by a number of mutations of the Mediterranean fever (MEFV) gene, coding a protein named pyrin that acts as a major regulatory component of the inflammasome.The first-line ...
Fukushima, Chizu, Kawakami, Atsushi, Chizu Fukushima, Arinaga, Kumiko, Yamamoto, Hiroshi, Junya Miyamoto, Sato, Shuntaro, Koga, Tomohiro, Kawazoe, Yurika, Junya Miyamoto (6164702), Atsushi Kawakami (398370), Chizu Fukushima (6164714), Yurika Kawazoe, Hagimori, Naoko, Tomohiro Koga, Naoko Hagimori, Kumiko Arinaga (6164711), Kumiko Arinaga, Hiroshi Yamamoto, Naoko Hagimori (6164705), Tomohiro Koga (398369), Shuntaro Sato (4025585), Hiroshi Yamamoto (28534), Shuntaro Sato, Atsushi Kawakami, Yurika Kawazoe (6164708), Miyamoto, Junya   +26 more
core   +1 more source

Reducing length of hospital stay with colchicine

Journal of Infection in Developing Countries, 2022
Introduction: Colchicine is an ancient agent with well-known anti-inflammatory effects and commonly used in treatment of hyperinflammatory conditions.
Özlem Karakaş, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Enes Seyda Sahiner, Ali Can Kurtipek, Osman Inan, Emin Gemcioglu, İhsan Ateş, Ahmet Omma, Orhan Küçüksahin   +10 more
doaj   +1 more source

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

PLoS ONE, 2019
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses.
Harutyun Sahakyan, Narek Abelyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan   +4 more
doaj   +1 more source

Biosynthesis of Colchicine [PDF]

Nature, 1960
OF several proposals1–4 concerning the biogenesis of the alkaloid colchicine (5; R 1 = R 2 = Me), only that of Wenkert4 involves the intervention of an intact tropolone ring prior to formation of ring B.
openaire   +2 more sources