Results 51 to 60 of about 78,062 (255)

UV micro-irradiation of the Chinese hamster cell nucleus and caffeine post-treatment immunocytochemical localization of DNA photolesions in cells with partial and generalized chromosome shattering [PDF]

, 1983
UV micro-irradiation of a small part of the Chinese hamster nucleus and caffeine post-incubation often results in shattered chromosomes at the first post-irradiation mitosis.
Cornelis, Cornelis, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Deaven, Fukuda, Gray, Hsu, Kihlman, Lehmann, Nilsson, Stack, Stubblefield, Taylor, Zorn, Zorn   +26 more
core   +1 more source

Molecular Docking and Dynamics Simulation Reveal Stable Binding of Tiliroside in the Colchicine Site of Tubulin

Journal of Pharmacy and Bioallied Sciences
Background: The colchicine-binding site on tubulin is of particular interest for new drug development due to its role in microtubule destabilization and potential to overcome resistance to other agents.
Hani Z. Asfour, Hagar M. Mohamed, Abdelsattar M. Omar, Nabil A. Alhakamy, Gamal A. Mohamed, Dina S. El-Agamy, Sabrin R.M. Ibrahim   +6 more
doaj   +1 more source

Effectiveness of colchicine among patients with COVID-19 infection: A randomized, open-labeled, clinical trial

Indian Journal of Rheumatology, 2022
Background and Objective: In November 2019, there were abundant cases of COVID-19 which first case was reported in Wuhan, China. Colchicine has an important role in inhibiting activation of NLRP3 inflammasome that predispose to decrease cytokine ...
Aryan Mohamadfatih Jalal, Sheelan Faroz Aref, Dashty Abbas Albustany   +2 more
doaj   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Role of the cellular environment in interstitial stem cell proliferation in Hydra [PDF]

, 1991
The role of the cellular environment on hydra stem cell proliferation and differentiation was investigated by introduction of interstitial cells into host tissue of defined cellular composition.
Bosch, Thomas C. G., David, Charles N., Rollbühler, Rebecca, Schneider, Birgit   +3 more
core   +1 more source

Oxygen Saturation in Hospitalized COVID-19 Patients and Its Relation to Colchicine Treatment: A Retrospective Cohort Study with an Updated Systematic Review

Medicina, 2023
Background: Colchicine has been proposed as a cytokine storm-blocking agent for COVID-19 due to its efficacy as an anti-inflammatory drug. The findings of the studies were contentious on the role of colchicine in preventing deterioration in COVID-19 ...
Sandy Sharaf, Rasha Ashmawy, Eman Saleh, Mayada Salama, Yousra A. El-Maradny, Ali Zari, Shahinda Aly, Ahmed Tolba, Doaa Mahrous, Hanan Elsayed, Dalia Latif, Elrashdy M. Redwan, Ehab Kamal   +12 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Seed Germination and Seedling Growth of Dendrocalumus brandisii in vitro, and the Inhibitory Mechanism of Colchicine

Frontiers in Plant Science, 2021
Bamboos seldom bloom and almost no seeds could be harvested, and, hence, few works are focused on germination physiology. Systematic research on the physiological effects of colchicine on germination and seedling growth of bamboo seeds is lacking.
Zhuo Lv, Zhuo Lv, Fangwei Zhu, Fangwei Zhu, Diankun Jin, Diankun Jin, Yufang Wu, Yufang Wu, Shuguang Wang, Shuguang Wang   +9 more
doaj   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

LC-MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs [PDF]

, 2017
Clinical evaluation of a colchicine specific antigen-binding fragment (Fab) in order to treat colchicine poisoning required the development of an accurate method allowing quantification of free and Fab-bound colchicine in plasma and urine, and free ...
Abe, Adrian Thompson, Aghabiklooei, Amrollahi-Sharifabadi, Babu, Baud, Ben-Chetrit, Bodeau, Evereklioglu, Ferron, Folpini, Gumm, Halkin, Jean-Claude Alvarez, Jiang, Julien Allard, Kintz, Kintz, Luduena, Marine Sardaby, Maurizi, Medlej-Hashim, Michael Eddleston, Nicolas Fabresse, Niel, Peake, R. Eddie Clutton, Roberts, Rochdi, Rochdi, Sabouraud, Sabouraud, Scherrmann, Smith, Smith, Walaszek, Wallace, Wollersen   +37 more
core   +1 more source