Results 51 to 60 of about 16,654 (233)
RMD Open, 2021 Objective To evaluate whether the addition of colchicine to standard treatment for COVID-19 results in better outcomes.Design We present the results of a randomised, double-blinded, placebo-controlled clinical trial of colchicine for the treatment of ...
Maria Isabel Lopes +33 more
doaj +1 more source
, 2020 Introduction: Colchicine is an anti-inflammatory drug prescribed for numerous medical conditions. Side effects are frequently encountered, particularly gastrointestinal symptoms.
Yaxley, W, Yaxley, J, Scott, T
core +1 more source
Endocan: A Novel Marker for Colchicine Resistance in Familial Mediterranean Fever Patients?
Frontiers in Pediatrics, 2021 Introduction: Familial Mediterranean fever (FMF) patients had 5–10% colchicine resistance. Although FMF attacks are characterized by acute phase elevation, there are no biomarkers that can show colchicine resistance yet.
Ahmet Omma +7 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang +4 more
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesBackground: The colchicine-binding site on tubulin is of particular interest for new drug development due to its role in microtubule destabilization and potential to overcome resistance to other agents.
Hani Z. Asfour +6 more
doaj +1 more source
Antitumor and structure antioxidant activity relationship of Colchicine on Ehrlich ascites Carcinoma (EAC) in Female Mice [PDF]
, 2014 Colchicine has been reported to play important roles in hepatoprotection, anti-inflammation in vitro anti cancer activity. The present study was initiated to evaluate antioxidant and anti-cancer effects of colchicine (10µg/mice, i.p.) in mice after ...
Boshra, Sylvia A; Biochemistry Department, Faculty of Pharmacy, October 6 University, 6th October city, Egypt +1 more
core +2 more sources
Indian Journal of Rheumatology, 2022 Background and Objective: In November 2019, there were abundant cases of COVID-19 which first case was reported in Wuhan, China. Colchicine has an important role in inhibiting activation of NLRP3 inflammasome that predispose to decrease cytokine ...
Aryan Mohamadfatih Jalal +2 more
doaj +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Medicina, 2023 Background: Colchicine has been proposed as a cytokine storm-blocking agent for COVID-19 due to its efficacy as an anti-inflammatory drug. The findings of the studies were contentious on the role of colchicine in preventing deterioration in COVID-19 ...
Sandy Sharaf +12 more
doaj +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source