Results 71 to 80 of about 5,505 (208)

3D‐Printed Electroanatomic Twins of Cadaveric Cochleae: A Platform for Cochlear Implant Testing

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objectives Cochlear implants (CIs) can restore hearing to individuals with severe deafness, yet clinical outcomes vary widely because it remains difficult to predict how electrical currents interact with the unique anatomy of each cochlea. A central challenge in auditory rehabilitation is the lack of experimental systems that capture both the ...
Chloe Swords   +7 more
wiley   +1 more source

Effect of cochlear implant electrode insertion on middle-ear function as measured by intra-operative laser Doppler vibrometry [PDF]

open access: yes, 2009
Hypothesis: The aim of this study was to investigate the impact of cochlear implant electrode insertion on middle-ear low frequency function in humans.Background: Preservation of residual low frequency hearing with addition of electrical speech ...
Donnelly, N   +6 more
core  

The Effect Sodium Salicylate on Concentration of Unknown Compound in Perilymph of Guinea Pig

open access: yes, 1993
There are some evidences that temporary hearing loss is induced by disturbance of cochlear microcirculation due to the inhibition of prostaglandin synthesis by salicylate, however, the mechanism of salicylate ototoxicity has been still under study ...
김혜진   +3 more
core   +1 more source

Regional Impedance Patterns in Cochlear Implantation: Influence of Demographic and Early Activation

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
Implantation age is a key determinant of electrode impedance behavior, with a region‐specific effect most pronounced in the apical cochlea. Younger recipients exhibit higher intraoperative impedance followed by a time‐dependent reversal at 6 months.
Eman Hajr   +4 more
wiley   +1 more source

Intraspecific variation of cochlear morphology in bowhead and beluga whales

open access: yesThe Anatomical Record, Volume 309, Issue 6, Page 1514-1529, June 2026.
Abstract The bony labyrinth of the petrosal bone, a distinctive feature of mammal skulls, is often identified in micro‐computed tomography imaging to infer species' physiological and ecological traits. When done as part of a comparative study, one individual specimen is normally considered representative of a species, and intraspecific variation is ...
John Peacock, J. G. M. Thewissen
wiley   +1 more source

Development and performance of a biomimetic artificial perilymph for in vitro testing of medical devices

open access: yes, 2019
Objective. Cochlear implants interface with the fluid in the cochlea called perilymph. The volume of this fluid present in human and animal model cochlea is prohibitively low for isolation for in vitro studies.
Palmer, JC   +7 more
core   +1 more source

Drug selection for inner ear therapy

open access: yesFrontiers in Pharmacology
IntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
doaj   +1 more source

Mannitol and the blood-labyrinth barrier

open access: yesJournal of Otolaryngology - Head and Neck Surgery, 2017
Background Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform.
Trung N. Le, Brian W. Blakley
doaj   +1 more source

A Case of Multiple Perilymph Fistula Induced by Tympanostomy Tube Insertion [PDF]

open access: yes, 2010
This controversial diagnosis centers around the phenomenon of perilymph leaking from the inner ear into the middle ear cleft through the oval window, round window or other fissures in the bony labyrinth that may be abnormally patent.
김미주
core  

Evaluation of prednisolone and prednisolone sodium succinate concentrations in human plasma and inner ear perilymph during cochlear implantation 24 h after intratympanic injection

open access: yes, 2022
Background: The use of intratympanic (IT) steroids has drastically increased over the past 10-15 years to manage many otological pathologies. Objectives: This study aimed to compare the concentrations of prednisolone and prednisolone sodium succinate ...
Chiara Filippi   +6 more
core   +1 more source

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