Results 121 to 130 of about 4,280,016 (306)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Perinatal determinants of depressive disorder profile in high-income women: testing current cut-off thresholds

BMC Psychiatry
Background Although the Edinburgh Postnatal Depression Scale (EPDS) is not diagnostic for antenatal and postpartum depressive disorders, understanding perinatal risk factors is crucial for the early identification of women’s risk profiles and for ...
Zanardo Vincenzo, Straface Gianluca, Romagnoli Daniele, Camporese Antonio, Sandri Sara, Suppiej Agnese, Luca Brugnaro, Battistin Tiziana   +7 more
doaj   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Prenatal Diagnosis of Pentalogy of Cantrell With Craniorachischisis by Three-Dimensionalultrasonography in the First Trimester

Taiwanese Journal of Obstetrics & Gynecology, 2009
Susumu Murata, Masahiko Nakata, Masahiro Sumie, Masakazu Mastsuabra, Norihiro Sugino   +4 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Biology of the endothelium: literature review

Revista Médica del Hospital General de México
Extensive research has been dedicated to elucidating the intricate pathophysiological mechanisms underlying endothelial dysfunction. Restoration of endothelial integrity is primarily achieved via two mechanisms: local endothelial cell proliferation and ...
Jésser M. Herrera-Salgado, Sergio G. Monasterios-López, Jhon E. Martínez-Alcalá, Waldemar A. Solis-Loria, María V. López-Parra, Hever J. Arriaga-Flores, Ana E. Montes-García, Érika K. Fuentes-Gutiérrez, Araceli Sevilla-Cano, Martín Rodríguez-Roldán, Luis E. Reyes-Mendoza, Freddy Mendoza-Hernández, Karina Mendoza-Mejía, Ricardo M. Malagón-Reyes, Ma. de Jesús Ángeles-Vázquez, Rubén Castorena-de Ávila, Jesús C. Briones-Garduño, Hugo Mendieta-Zerón, Sindy A. Gutiérrez-Chavarría   +18 more
doaj  

A British Pharmacological Society Position Statement on Medications in Pregnancy and Lactation

British Journal of Clinical Pharmacology, EarlyView.
Agnesa Mustafa, Cleodie C. Swire, Reya V. Shah, Bernadette Jenner, Rory H. McLean, Muhammad Shamsher Ahmed, Adrie Bekker, Julia Zöllner, Rachel K. Scott, Robert R. Bies, Sara K. Quinney, Dagan O. Lonsdale, Emma Forton Magavern, Catriona Waitt, Anita Banerjee   +14 more
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Romancing the Carer - Intimate Relationships and Family Caring

, 2017
The topic of sexuality and romantic intimacy is not an easy one for many to discuss; in particular is it is often seen as secondary to the difficulties being faced in other aspects of life and in the relationship.
Care Alliance Ireland
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