Results 71 to 80 of about 2,397,813 (251)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

From fix to fit into the autoptic human brains

European Journal of Histochemistry, 2018
Formalin-fixed, paraffinembedded (FFPE) human brain tissues are very often stored in formalin for long time. Formalin fixation reduces immunostaining, and the DNA/RNA extraction from FFPE brain tissue becomes suboptimal.
Beatrice Paradiso, Michele Simonato, Gaetano Thiene, Anna Lavezzi   +3 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Child Death, Near Death and Stillbirth Commission Annual Report for Calendar Year 2013

, 2015
2013 annual report of the Child Death, Near Death and Stillbirth ...
Child Death, Near Death and Stillbirth Commission
core   +2 more sources

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Perinatal death triples the prevalence of postpartum depression among women in Northern Uganda: A community-based cross-sectional study.

PLoS ONE, 2020
IntroductionDeaths during the perinatal period remain a big challenge in Africa, with 38 deaths per 1000 pregnancies in Uganda. The consequences of these deaths can be detrimental to the women; some ending up with postpartum depression.
Anna Agnes Ojok Arach, Noeline Nakasujja, Victoria Nankabirwa, Grace Ndeezi, Juliet Kiguli, David Mukunya, Beatrice Odongkara, Vincentina Achora, Justin Bruno Tongun, Milton Wamboko Musaba, Agnes Napyo, Vivian Zalwango, Thorkild Tylleskar, James K Tumwine   +13 more
doaj   +1 more source

CAUSES AND RECURRENCE RISK OF PERINATAL LOSS

Gomal Journal of Medical Sciences, 2017
Background: Perinatal death refers to death of fetus or newborn around the time of delivery and includes both fetal deaths (at least 20 weeks of gestation) and early neonatal deaths.
Fouzia Shaikh, Sabreena Abbas, Tahira Majeed, Sajida Yousfani   +3 more
doaj  

Recurrence of perinatal death in Northern Tanzania: a registry based cohort study [PDF]

, 2013
Background Perinatal mortality is known to be high in Sub-Saharan Africa. Some women may carry a particularly high risk which would be reflected in a high recurrence risk.
Obure, Joseph, Blandina T Mmbaga, Manongi, Rachel, Rachel Manongi, Lie, Rolv T., Joseph Obure, Michael J Mahande, Gileard Masenga, Mahande, Michael Johnson, Anne K Daltveit, Mmbaga, Blandina T., Daltveit, Anne Kjersti, Masenga, Gileard, Rolv T Lie, Lie, Rolv Terje, Mmbaga, Blandina Theophil   +15 more
core   +2 more sources

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Reflections on Doing Research Grounded in My Experience of Perinatal Loss: From Auto/biography to Autoethnography [PDF]

This article, derived from my doctoral dissertation (Davidson 2007) examining the emergence of hospital protocols for perinatal bereavement during the last half of the twentieth century in Canada, focuses on the methodological complexities – the draw ...
Deborah Davidson
core