Impact of perinatal hypoxia on the developing brain. [PDF]
Physiol Res, 2020 Perinatal hypoxia is still one of the greatest threats to the newborn child, even in developed countries. However, there is a lack of works which summarize up-to-date information about that huge topic. Our review covers a broader spectrum of recent results from studies on mechanisms leading to hypoxia-induced injury.
Piešová M, Mach M.
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Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. [PDF]
Ann Clin Transl Neurol, 2022 Neonatal encephalopathy (NE) is an important cause of mortality and disability worldwide. Therapeutic hypothermia (HT) is an effective therapy, however not all babies benefit. Novel agents are urgently needed to improve outcomes. Melatonin in preclinical
Pang R +5 more
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The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries [PDF]
Frontiers in Cell and Developmental Biology, 2022 This study was designed in a rat model to determine the hallmarks of possible permanent behavioral and structural brain alterations after a single moderate hypoxic insult.
Sara Trnski +13 more
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Am J Physiol Heart Circ Physiol, 2021 BACKGROUND Compared to acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic ...
Romanowicz J +10 more
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Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells. [PDF]
Mol Neurobiol, 2020 Differentiation of oligodendrocyte progenitors towards myelinating cells is influenced by a plethora of exogenous instructive signals. Insulin-like growth factor 1 (IGF-1) is one of the major factors regulating cell survival, proliferation, and ...
Janowska J +4 more
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Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult. [PDF]
Cell Death DifferCold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs and promoting their translation. Neurons subjected to hypobaric hypoxia insult trigger various cell death
Zhu X +6 more
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Perinatal hypoxia-mediated neurodevelopment abnormalities in congenital heart disease mouse model [PDF]
Molecular MedicineBackground Cyanotic congenital heart disease (CHD) in children has been associated with neurodevelopmental abnormalities, although the underlying mechanisms remain largely unknown. Multiple factors are likely involved in this process.
Renwei Chen +7 more
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Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia. [PDF]
Front Psychiatry, 2018 Intrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life.
Hefter D, Marti HH, Gass P, Inta D.
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Umbilical markers of perinatal hypoxia
Polish Gynaecology, 2016 The aim of the study was to evaluate activin A and NGAL levels as potential early markers of perinatal hypoxia.We prospectively studied 58 full-term newborns: 24 with perinatal hypoxia (study group) and 34 healthy controls. Umbilical cord blood samples were obtained from all subjects immediately after delivery for the measurement of activin A and NGAL ...
Małgorzata, Fiala +4 more
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Pediatrics and Neonatology, 2013 Perinatal hypoxia can lead to a wide range of neurological deficits depending on the differential vulnerability of the involved brain regions to oxygen deprivation.
Yung-Ning Yang +5 more
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