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Cortical neurogenesis enhanced by chronic perinatal hypoxia
Experimental Neurology, 2006Most regions of the mature mammalian brain, including the cerebral cortex, appear to be unable to support the genesis of new neurons. Here, we report that a low level of neurogenesis occurs in the cerebral cortex of the infant mouse brain and is enhanced by chronic perinatal hypoxia. When mice were reared in a low-oxygen environment from postnatal days
Devon M, Fagel +7 more
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Perinatal hypoxia and subsequent development of seizures
Physiology & Behavior, 1985Perinatal asphyxia has been implicated in the pathogenesis of persistent convulsive disorders later in life. Whether epilepsy is the result of oxygen deficiency alone or is due to the combined effect of hypoxia and ischemia is not known. In this report we studied the role of perinatal hypoxia alone on the development of epilepsy.
S L, Moshé, B J, Albala
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New concepts in perinatal hypoxia ischemia encephalopathy
Current Neurology and Neuroscience Reports, 2008This article summarizes recent insights into perinatal hypoxic-ischemic brain injury in the neonate. Before effective treatments can be offered, diagnosis, timing, and an understanding of the pathogenesis are imperative. The analysis of appropriate animal models is also summarized in this review.
Joseph, Scafidi, Vittorio, Gallo
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The Relationship Between Perinatal Hypoxia and Newborn Encephalopathy
Survey of Anesthesiology, 1985Newborn encephalopathy was observed in 30% of 303 selected high-risk preterm and term newborn infants. The newborn encephalopathy was mild or moderate in 65 children and severe in 27. The predictive significance of newborn encephalopathy to motor and cognitive deficits at 1 year was evident from the incidence of deficits in the children with no ...
J A, Low +5 more
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Potential New Therapies for Perinatal Cerebral Hypoxia-Ischemia
Clinics in Perinatology, 1993Recent studies in neonatal animals have shown that hypoxic-ischemic brain damage can be reduced by interventions initiated after the hypoxic-ischemic insult. In this article, the authors focus on potentially new modalities of therapy capable of preventing--or at least reducing--brain damage arising from perinatal cerebral hypoxia-ischemia.
C, Palmer, R C, Vannucci
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Management of renal dysfunction following term perinatal hypoxia‐ischaemia
Acta paediatrica, 2013Acute kidney injury frequently develops following the term perinatal hypoxia‐ischaemia. Quantifying the degree of acute kidney injury is difficult, however, as the methods currently in use are suboptimal.
D. Sweetman, M. Riordan, E. Molloy
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Is Hypoxanthine a Useful Marker of Perinatal Hypoxia?
1995Perinatal hypoxia is one of the major causes of morbidity and mortality of newborns and was therefore intensively studied (O’Connor et al., 1981; Saugstadt and Gluck, 1982; Ripalda et al., 1989; Gloeckner and Kretschmar, 1991). Each kind of oxygen deficiency is combined with an accelerated purine degradation and therefore an accelerated formation of ...
T, Grune +4 more
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Effects of Hypoxia on Perinatal Drug Disposition
2021Clinical pharmacology intends to predict drug-related effects based on drug- and population-specific pharmacokinetics (PK, concentration-time, disposition), and pharmacodynamics (PD, concentration-effect), including intra- and interindividual variability.
Allegaert, Karel +2 more
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Radionuclide Brain‐scanning in Perinatal Hypoxia/Ischemia
Developmental Medicine & Child Neurology, 1979SUMMARYRadionuclide brain‐scans employing Technetium‐99m pertechnetate were performed in the neonatal period on 85 full‐term newborns with neurological symptons secondary to perinatal hypoxia/ischemia. The brain scan was abnormal in 56 of the infants.The early neurological and developmental progress of these infants has been studied; follow‐up ...
M. John O'Brien +2 more
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An animal model of hypoxia-induced perinatal seizures
The Italian Journal of Neurological Sciences, 1995Clinically, neonatal hypoxic encephalopathy is commonly associated with seizure activity. Here we describe a rodent model of cerebral hypoxia in which there is are age dependent effects of hypoxia, with hypoxia inducing seizure activity in the immature rat, but not in the adult. Global hypoxia (3-4% O2) induced acute seizure activity during a window of
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