Results 81 to 90 of about 497,285 (309)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Balance of Antioxidants vs. Oxidants in Perinatal Asphyxia

Applied Sciences
Perinatal asphyxia refers to an acute event of cerebral ischemia and hypoxia during the perinatal period, leading to various degrees of brain injury. The mechanisms involved in perinatal asphyxia include the production of reactive oxygen species (ROS ...
Dimitrios Rallis, Niki Dermitzaki, Maria Baltogianni, Konstantina Kapetaniou, Vasileios Giapros   +4 more
doaj   +1 more source

Distinct Mechanisms Underlie Developmental Plasticity and Adult Acclimation of Thermogenic Capacity in High-Altitude Deer Mice

Frontiers in Physiology, 2021
Developmental plasticity can elicit phenotypic adjustments that help organisms cope with environmental change, but the relationship between developmental plasticity and plasticity in adult life (e.g., acclimation) remains unresolved. We sought to examine
Catherine M. Ivy, Haley Prest, Claire M. West, Graham R. Scott   +3 more
doaj   +1 more source

Impaired Metabolism Induced By Perinatal Hypoxia

International Journal of Innovative Research in Medical Science, 2016
Perinatal hypoxia induces disturbances in glucose metabolism. In anaerobic environment, high level of lactate production persists, causing endothelial damage and deleterious effect on the brain. The outcome depends on the brain capacity to utilize lactate and ketones as an alternative energy source to glucose.
Zisovska, Elizabeta, Trajkova, Kornelija
openaire   +3 more sources

Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [3H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals

Croatian Medical Journal, 2014
Aim To analyze the effects of highly selective blocker GAT1, NO-711, and substrate inhibitor GAT3, β-alanine, on the initial velocity of [3H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals (synaptosomes) after perinatal hypoxia ...
N. Pozdnyakova, M. Dudarenko, L. Yatsenko, N. Himmelreich, O. Krupko, Tatiana Borisova   +5 more
semanticscholar   +1 more source

Can the cerebroplacental ratio (CPR) predict intrapartum fetal compromise? : a prospective observational study [PDF]

, 2017
Objective: To investigate the potential clinical use of serial fetal CPR measurements during the last month of pregnancy for the prediction of adverse perinatal outcome in unselected low-risk pregnancies.
Dehaene, Isabelle, Page, Ann-Sophie, Page, Geert, Roelens, Kristien, Roets, Ellen   +4 more
core   +1 more source

Evaluating predictive values of umbilical cord arterial lactate for adverse newborn outcomes among term‐births in northern Uganda: A cross sectional analytical study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.
Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare, James K. Tumwine, Jolly Nankunda, Anna Hjelmstedt, Wibke Jonas, Grace Ndeezi, Nicola Orsini, Claudia Hanson   +7 more
wiley   +1 more source

The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats [PDF]

Korean Journal of Pediatrics, 2010
PurposeThe neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects ...
Moon Sun Kim, Yoo Kyung Seo, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim   +8 more
doaj   +1 more source

Neonatal multiple organ failure after perinatal asphyxia

Anales de Pediatría (English Edition), 2022
Perinatal asphyxia is an event with far-reaching consequences that can lead not only to the development of neonatal encephalopathy, but also to multiple organ failure (MOF).
Isabel Iribarren, Enrique Hilario, Antonia Álvarez, Daniel Alonso-Alconada   +3 more
doaj   +1 more source

Cerebral autoregulation, brain injury, and the transitioning premature infant [PDF]

, 2017
Improvements in clinical management of the preterm infant have reduced the rates of the two most common forms of brain injury, such as severe intraventricular hemorrhage and white matter injury, both of which are contributory factors in the development ...
Mathur, Amit M, Vesoulis, Zachary A
core   +3 more sources