Results 141 to 150 of about 17,637,970 (344)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

DOP013. Increase of Inflammatory Bowel Disease incidence in teenagers in a prospective population-based-study over a 21-year period (1988-2008) [PDF]

, 2015
S. Ghione, H. Sarter, Laura Armengol‐Debeir, Mathurin Fuméry, Guillaume Savoye, Luc Dauchet, Delphine Ley, Claire Spyckerelle, O. Mouterde, D. Djeddi, Benjamin Pariente, Laurent Peyrin‐Biroulet, D. Turck, Corinne Gower‐Rousseau   +13 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Autistic mothers and the perinatal period: Maternal experiences and infant development

, 2020
Sarah Hampton
openalex   +1 more source

Thirteenth Biennial Report of the Florida Geological Survey, Covering Period January 1, 1957, Through December 31, 1958 [PDF]

, 1959

openalex   +1 more source

Youth Political Mobilization in Tharaka-North during the Colonial Period between 1895 and 1963

, 2023
Jacklin Mwikali Mwangangi, Isaiah Oduor, Ambrose Vengi   +2 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Comparing and Investigating the Effects of Bi-level Non-Invasive Ventilator with High and Low Inspiratory Pressure in a Group of Patients Suffering from COPD Exacerbation over the Period of 2015-2016

, 2016
Farzaneh Ghaemi, Besharat Rahimi
openalex   +1 more source

Critical Period of Weed Interference_Lettuce_AV_Raw Data

, 2022
Alessandra Virili, Anna‐Camilla Moonen
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source