Results 101 to 110 of about 4,930,166 (237)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Limit cycles bifurcations of Liénard system with a hyperelliptic Hamiltonian of degree five
Electronic Journal of Qualitative Theory of Differential EquationsWe deal with limit cycles bifurcating from the period annulus of Liénard system with a hyperelliptic Hamiltonian of degree five under quartic perturbation, where Liénard system has a normal form $\dot{x}=y$, $\dot{y}=x(x-1)(x^{2}+ax+b)$, $a^{2 ...
Yi Shao, Chunxiang A
doaj +1 more source
Mathematical and Computer Modelling, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Xuefang Li, Zhaoxia Wang 0005
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Selective, segmental decalcification: a safe alternative to extensive debridement of a severely calcified annulus during repair of mitral regurgitation. [PDF]
, 2016 Resection of the calcium bar and creation of a more compressible annulus with pericardium are necessary in case of extensive calcification of the mitral valve annulus in patients with advanced myxomatous degenerative disease.
Carrel, Thierry +2 more
core +3 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The Cyclicity of Period Annulus of Cubic Isochronous Hamiltonian Systems
Cima, Mañosas and Villadelprat (J. Differ. Equations, 157, 373--413, 1999) proved that a cubic Hamiltonian system possesses an isochronous center at the origin if and only if its Hamiltonian function can be expressed as \begin{eqnarray*}H_1(x,y)=k_1^2x^2+(k_2y+k_3x+k_4x^2)^2, \end{eqnarray*} where $k_1,k_2,k_3,k_4\in\mathbb{R}$, $k_1k_2\neq0$.
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Curling of a Heated Annulus [PDF]
, 2016 We study the large-displacement behavior of a thin annulus subjected to thermal gradients. Following axisymmetrical deflections, the annulus buckles into a periodic mode shape, which eventually forms a number of a radial curls under sustained heating. We
core +2 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source