Results 91 to 100 of about 919,380 (301)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Occupant comfort, the housing industry and electricity infrastructure: understanding the synergies [PDF]
, 2012 Despite increasingly stringent energy performance regulations for new homes, southeast Queensland has a high and growing penetration of, and reliance on, air conditioners to provide thermal comfort to housing inhabitants.
Miller, Wendy, Shah Nazari, Hoda
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
UK domestic air conditioning: a study of occupant use and energy efficiency [PDF]
, 2008 This paper presents the results of a study of air-conditioning usage in homes in the southeast of England. First part of the study consisted surveying 13 dwellings with air-conditioning for a series of 4 week periods during the summer of 2004.
Oreszczyn, T., Pathan, A., Young, A.
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Late Antique Residences at Golemo Gradište, Konjuh, R. Macedonia
, 2013 The systematic excavations that began at Golemo Gradište in 2000 were the first major, legal investigations on the site itself. Through survey of the site, researchers had reached a number of conclusions and hypotheses about lines of fortification walls,
Sanev, Goran, Snively, Carolyn S.
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Using GIS to Evaluate the Effects of Flood Risk on Residential Property Values [PDF]
, 2000 Annually, flooding causes more property damage in the United States than any other type of natural disaster. One of the consequences of continued urbanization is the tendency for floodplains to expand, increasing flood risks in the areas around urban ...
Bartosova, Alena +3 more
core +1 more source
Air ion behavior in ventilated rooms
, 2008 Air ionizers have seen increasing use as devices for improving indoor air quality, including applications designed to reduce the transmission of infection in healthcare environments.
Beggs, C.B. +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source