Results 111 to 120 of about 634,594 (289)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Periodic breathing during ascent to extreme altitude quantified by spectral analysis of the respiratory volume signal

, 2012
High altitude periodic breathing (PB) shares some common pathophysiologic aspects with sleep apnea, Cheyne-Stokes respiration and PB in heart failure patients.
J. P. Hefti, M. Maggiorini, Maggiorini, M, Giraldo, B F, Hefti, U, T. M. Merz, A. J. Turk, Merz, T M, K. E. Bloch, U. Hefti, A. Garde, Schoch, O D, Garde, A, Barthelmes, D, Jane, R, Hess, T, Latshang, T D, Bosch, M M, T. D. Latshang, B. F. Giraldo, Turk, A J, Hefti, J Pichler, T. Hess, R. Jane, O. D. Schoch, D. Barthelmes, Bloch, K E, M. M. Bosch   +27 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Effects of hyperventilation length on muscle sympathetic nerve activity in healthy humans simulating periodic breathing. [PDF]

Front Physiol, 2022
Spiesshoefer J, Giannoni A, Borrelli C, Sciarrone P, Husstedt I, Emdin M, Passino C, Kahles F, Dawood T, Regmi B, Naughton M, Dreher M, Boentert M, Macefield VG.   +13 more
europepmc   +1 more source

Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation

, 1998
This study aimed to investigate the effect of periodic breathing (PB) at high altitude on sleep structure and arterial oxygen saturation (Sa,O2). Five healthy subjects underwent polysomnographic studies at sea level, and during the first and the fourth ...
Lanfranchi P, Braghiroli A, Marrone O, Insalaco G, Patruno V, Romano S, Donner CF, Bonsignore G, Salvaggio A   +8 more
core   +1 more source

Thermochemical Core–Shell Architecturing of Si‐SWCNT Composites for High‐Performance Li‐Ion Battery Anodes

Advanced Science, EarlyView.
A thermochemically engineered core–shell Si architecture is developed through the controlled evolution of a SWCNT‐coated Mg2Si precursor. The process simultaneously generates a nanoporous Si shell for strain accommodation and Li+ transport, a chemically anchored SiC interfacial layer for robust mechanical and electrical coupling, and a Mg‐containing Si
Dong Gyun Hong, Byeong Guk Kim, Jung‐Hyeok Park, Sunwoo Lee, Donghwi Cho, Jaeik Hyun, Ki‐Hun Nam, Youngoh Kim, Geon‐Woong Lee, Sunhye Yang, Seung Yol Jeong, Myungwoo Choi   +11 more
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Ventilatory control instability as a predictor of persistent periodic breathing in preterm infants. [PDF]

Pediatr Res, 2022
Siriwardhana LS, Yee AK, Mann DL, Dawadi S, Nixon GM, Wong FY, Edwards BA, Horne RSC.   +7 more
europepmc   +1 more source

Chelation‐Driven Dual‐Interface Regulation for Long‐Life Aqueous Zn–I2 Batteries

Advanced Science, EarlyView.
Zn2+–TPEN coordination generates TPEN‐derived coordination species (TCC) that contribute to the regulation of both electrode interfaces. At the Zn anode, it creates an interfacial environment with reduced water accessibility that suppresses HER and corrosion while promoting uniform deposition; at the I2 cathode, it captures polyiodide to inhibit ...
Dong Wook Kim, Seung Hwa Park, Tae Rim Kim, Gun Jang, Jun Su Kim, Myung‐Jun Kwak, Seokhwan Jin, Seongbin Ga, Chihyun Hwang, Ho Seok Park, Youngkwon Kim   +10 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source