Results 121 to 130 of about 110,313 (345)

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

On Using Curvature to Demonstrate Stability

open access: yesDifferential Equations and Nonlinear Mechanics, 2008
A new approach for demonstrating the global stability of ordinary differential equations is given. It is shown that if the curvature of solutions is bounded on some set, then any nonconstant orbits that remain in the set, must contain points that lie ...
C. Connell McCluskey
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Precessing and periodic timelike orbits and their potential applications in Einsteinian cubic gravity

open access: yesEuropean Physical Journal C: Particles and Fields
Einsteinian cubic gravity (ECG) is the most general theory up to cubic order in curvature, which has the same graviton spectrum as the Einstein theory. In this paper, we investigate the geodesic motions of timelike particles around the four dimensional ...
Yong-Zhuang Li, Xiao-Mei Kuang, Yu Sang
doaj   +1 more source

Dynamics of shear homeomorphisms of tori and the Bestvina-Handel algorithm

open access: yes, 2011
Sharkovskii proved that the existence of a periodic orbit in a one-dimensional dynamical system implies existence of infinitely many periodic orbits. We obtain an analog of Sharkovskii's theorem for periodic orbits of shear homeomorphisms of the torus ...
Pinsky, Tali, Wajnryb, Bronislaw
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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