Results 121 to 130 of about 14,302 (311)

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Numerical continuation of canard orbits in slow-fast dynamical systems

, 2009
A trajectory of a system with two clearly separated time scales generally consists of fast segments (or jumps) followed by slow segments where the trajectory follows an attracting part of a slow manifold. The switch back to fast dynamics typically occurs
Desroches, MF, Osinga, HM, Krauskopf, B
core   +1 more source

Infinite number of stable periodic solutions for an equation with negative feedback

Electronic Journal of Qualitative Theory of Differential Equations, 2011
For all $\mu>0$, a locally Lipschitz continuous map $f$ with $xf\left(x\right)>0$, $x\in\mathbb{R}\setminus\left\{ 0\right\} $, is constructed, such that the scalar equation $\dot{x}\left(t\right)=-\mu x\left(t\right)-f\left(x\left(t-1\right)\right ...
Gabriella Vas
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Period-Multiplying Bifurcations in the Gravitational Field of Asteroids

Aerospace
Periodic orbit families around asteroids serve as potential trajectories for space probes, mining facilities, and deep space stations. Bifurcations of these families provide additional candidate orbits for efficient trajectory design around asteroids ...
P. Rishi Krishna, Joel George Manathara
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Universal twinkling exponents for spectral fluctuations associated with mixed chaology [PDF]

, 2000
For systems that are neither fully integrable nor fully chaotic, bifurcations of periodic orbits give rise to semiclassically emergent singularities in the fluctuating part Nfl of the energy-level counting function. The bifurcations dominate the spectral
Keating, J. P., Schomerus, H., Berry, MV, Keating, JP, Schomerus, H, Berry, M. V.   +5 more
core  

Periodic Orbits with Least Period Three on the Circle

Fixed Point Theory and Applications, 2008
The self-maps on the circle having periodic orbits with least period 3 are classified into relative homotopy-conjugacy classes. We will show that except for the maps in one exceptional class, all these kinds of maps have periodic orbits with all least ...
Xuezhi Zhao
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source