Results 81 to 90 of about 10,744 (292)
Infinite number of stable periodic solutions for an equation with negative feedback
Electronic Journal of Qualitative Theory of Differential Equations, 2011 For all $\mu>0$, a locally Lipschitz continuous map $f$ with $xf\left(x\right)>0$, $x\in\mathbb{R}\setminus\left\{ 0\right\} $, is constructed, such that the scalar equation $\dot{x}\left(t\right)=-\mu x\left(t\right)-f\left(x\left(t-1\right)\right ...
Gabriella Vas
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Period-Multiplying Bifurcations in the Gravitational Field of Asteroids
AerospacePeriodic orbit families around asteroids serve as potential trajectories for space probes, mining facilities, and deep space stations. Bifurcations of these families provide additional candidate orbits for efficient trajectory design around asteroids ...
P. Rishi Krishna, Joel George Manathara
doaj +1 more source
Completely periodic directions and orbit closures of many pseudo-Anosov Teichmueller discs in Q(1,1,1,1) [PDF]
, 2011 Pascal Hubert +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Periodic Orbits with Least Period Three on the Circle
Fixed Point Theory and Applications, 2008 The self-maps on the circle having periodic orbits with least period 3 are classified into relative homotopy-conjugacy classes. We will show that except for the maps in one exceptional class, all these kinds of maps have periodic orbits with all least ...
Xuezhi Zhao
doaj +1 more source
Computation of periodic orbits in three‐dimensional Lotka‐Volterra systems [PDF]
, 2017 Juan F. Navarro, Rubén Poveda
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source