Results 81 to 90 of about 14,302 (311)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

New periodic orbits in the solar sail restricted three body problem

open access: yes, 2008
In this paper we consider periodic orbits of a solar sail in the Earth-Sun restricted three-body problem. In particular, we consider orbits which are high above the ecliptic plane, in contrast to the classical Halo orbits about the collinear equilibria ...
Biggs, J.D., Waters, Thomas, McInnes, C.
core  

Invariant manifolds and orbit control in the solar sail three-body problem

open access: yes, 2008
In this paper we consider issues regarding the control and orbit transfer of solar sails in the circular restricted Earth-Sun system. Fixed points for solar sails in this system have the linear dynamical properties of saddles crossed with centers; thus ...
Waters, Thomas   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Displaced geostationary orbits using hybrid low-thrust propulsion [PDF]

open access: yes, 2012
In this paper, displaced geostationary orbits using hybrid low-thrust propulsion, a complementary combination of Solar Electric Propulsion (SEP) and solar sailing, are investigated to increase the capacity of the geostationary ring that is starting to ...
Biggs, James   +13 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Displaced periodic orbits with low-thrust propulsion

open access: yes, 2009
Solar sailing and solar electric technology provide alternative forms of spacecraft propulsion. These propulsion systems can enable exciting new space-science mission concepts such as solar system exploration and deep space observation.
Simo, Jules   +2 more
core  

Survey of highly non-Keplerian orbits with low-thrust propulsion

open access: yes, 2011
Celestial mechanics has traditionally been concerned with orbital motion under the action of a conservative gravitational potential. In particular, the inverse square gravitational force due to the potential of a uniform, spherical mass leads to a family
Biggs, James   +9 more
core   +1 more source

A Cr unimodal map with an arbitrary fast growth of the number of periodic points [PDF]

open access: yes, 2012
In this paper we present a surprising example of a C(r) unimodal map of an interval f : I -> I whose number of periodic points P(n)(f) = vertical bar{x is an element of I : f(n) x = x}vertical bar grows faster than any ahead given sequence along a ...
Kaloshin, V., Kozlovski, O.
core   +1 more source

Four- and five-body periodic Caledonian orbits

open access: yes, 2021
We consider four- and five-body problems with symmetrical masses (Caledonian problems). Families of periodic orbits originate from the collinear Schubart orbits.
Chopovda V, Sweatman W
core   +1 more source

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