Results 111 to 120 of about 13,692 (239)

Efficacy of Retigabine in Treating Weakness in a Mouse Model of Hypokalemic Periodic Paralysis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Hypokalemic periodic paralysis (HypoKPP) is an ion channelopathy causing episodic skeletal muscle weakness triggered by hypokalemia. Reduced inward rectifier K+ (Kir) channel activity contributes to membrane depolarization and paralysis, suggesting that pharmacologic activation of muscle K+ channels may restore excitability ...
Kirsten Denman, Mark M. Rich
wiley   +1 more source

Efficacy of a K+ Channel Agonist, XEN1101, For Preserving Contractility in Mouse Models of Hypokalemic Periodic Paralysis

Muscle &Nerve, EarlyView.
Pretreatment with an agonist of Kv7 potassium channels (XEN1101) protects the soleus muscle from a loss of force during a 2 mM K+ challenge, in a mouse model of hypokalemic periodic paralysis. ABSTRACT Introduction/Aims Effective management remains lacking for recurrent episodes of acute weakness in hypokalemic periodic paralysis (HypoPP).
Viktor Chanchykov, Sharon Iype, Marbella Quinonez, Fenfen Wu, Stephen Cannon   +4 more
wiley   +1 more source

Human CNTNAP1 Variants Associated With Severe Neurological Deficits: Additional Cases and Literature Review

Muscle &Nerve, EarlyView.
ABSTRACT CNTNAP1 encodes the Contactin‐Associated Protein 1 (CNTNAP1), also known as Caspr1, which is a transmembrane protein critical for nervous system function. CNTNAP1 is localized to the paranodal regions of all myelinated axons, flanking either side of the node of Ranvier.
Lacey B. Sell, Derek Garcia, Alexandra Hollá, Ilana Chilton, Seth DeVries, Ana María Gómez‐Moreno, Manuel Lubián‐Gutiérrez, Qian Shi, Manzoor A. Bhat   +8 more
wiley   +1 more source

Rehabilitation paired with vagus nerve stimulation for motor function of chronic ischemic stroke patients in China: Study protocol of a multicenter randomized controlled trial (Repair Study)

Neuroprotection, EarlyView.
Mechanism of vagus nerve stimulation (VNS) paired with movement: VNS activates cholinergic nucleus basalis and noradrenergic locus coeruleus neurons, modulating motor cortex activity (light green and red areas) in a task‐specific manner during targeted movements. VNS: vagus nerve stimulation.
Anchao Yang, Yong Liu, Hongxing Huang, Xiaoqin Sun, Dawei Zang, Jun Lu, Qingping Tang, Yulian Zhu, Qi Yue, Weining Wang, Guohui Lu, Lang Shuai, Jun Wang, Yunqian Li, Li Bie, Zhenlan Li, Guoxing Xu, Jinghui Li, Tao Ding, Yanwu Guo, Wen Wu, Yuting Xu, Yuanxiang Lin, Zhiyong Wang, Fuxin Lin, Chunhua Hang, Rong Xu, Xiangyu Liu, Wenjun Hong, Kai Shu, Min Lu, Feng Hu, Ruobing Qian, Ming Wu, Liuzhong Sun, Min Wu, Yingchuan Chen, Qian Wang, Sihao Liu, Qiao Zhang, Shiyi Zuo, Binxia Zhang, Wei Wu, Zhongming Wang, Huayang Deng, Lijuan Quan, Renli Qi, Wei Wang, Fuchuan Huang, Xiemin Liang, Feng Wang, Yalan Wang, Zejian Chen, Jiang Ran, Liang Chen, Jianguo Zhang, Ying Mao   +56 more
wiley   +1 more source

Do Policy Capacities Matter for Federal Policy Design? Evidence From the Implementation of Three Social Policies in Brazil

Public Administration and Development, EarlyView.
ABSTRACT Bringing together the literature on policy design, policy capacity and policy making in multilevel systems, this paper argues that the effectiveness of policy design in federal countries depends, ceteris paribus, on the adequacy of federal and local policy capacities.
Giliberto Capano, Vanessa Elias de Oliveira   +1 more
wiley   +1 more source

A dramaturgy of uncertainty: Transdisciplinary manoeuvres across forestry and theatre

People and Nature, EarlyView.
Abstract The uncertainties of climate change mean that forestry adaptation strategies are often complex and contested. Research has suggested that there is an interest in the forestry sector for facilitated dialogue about uncertainty (de Pellegrin Llorente et al., 2023).
Rachel Clive, Deirdre Heddon, Jordan Rydlewski, David Edwards, Chris Fremantle   +4 more
wiley   +1 more source

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology

PROTEOMICS, EarlyView.
ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong, Yuming Shi, Aleksandra Kozlova, Renata Moravcova, Jason C. Rogalski, Aidan Jamieson, Lance Lansing, Kyung‐Mee Moon, Xiaojing Yuan, Amanda S. Gregoris, Heather Higo, Julia Common, Ida M. Conflitti, Mateus Pepinelli, Lan Tran, Morgan Cunningham, Hosna Jabbari, Syed Abbas Bukhari, Sarah K. French, Rodrigo Ortega Polo, Shelley E. Hoover, Stephen F. Pernal, Pierre Giovenazzo, M. Marta Guarna, Amro Zayed, Leonard J. Foster   +25 more
wiley   +1 more source

Depressive symptoms in people with late effects of polio and the association with sociodemographic and disability‐related factors

PM&R, EarlyView.
Abstract Background Late effects of polio (LEoP) is a progressive condition leading to a lifelong disability that can affect mental health. There is limited knowledge of depressive symptoms and associated factors in people with LEoP. Objective To assess the occurrence of depressive symptoms in people with LEoP and explore the association with ...
Maria Nolvi, Christina Brogårdh, Lars Jacobsson, Jan Lexell   +3 more
wiley   +1 more source

Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms. [PDF]

Endocrinol Metab (Seoul)
Qing G, Zakaria WNA, Rom FZM, Nik WNFHW, Zulkeflee HA, Rahim SNA.   +5 more
europepmc   +1 more source

Potential of bacteria isolated from chitin‐enriched soil against Euschistus heros (Hemiptera: Pentatomidae)

Pest Management Science, EarlyView.
B. thuringiensis and B. altitudinis, isolated from chitin‐enriched soil, causing mortality in Euchistus heros under laboratory conditions. First report of B. altitudinis in the control of E. heros. Abstract BACKGROUND Biological control using entomopathogenic microorganisms is a more sustainable alternative to chemical pesticides for managing insect ...
Vicente Guilherme Handte, Valéria Ortaça Portela, Nariane de Andrade, Valdemir Bittencourt Soares, Andressa de Souza Pollo, Ricardo Antonio Polanczyk, Rodrigo Josemar Seminoti Jacques   +6 more
wiley   +1 more source