Results 121 to 130 of about 8,136,999 (366)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

New periodic exact traveling wave solutions of Camassa–Holm equation

open access: yesPartial Differential Equations in Applied Mathematics, 2022
In Zhang et al. (2007) and Zhang (2021) we constructed all single-peak traveling wave solutions of the Camassa–Holm equation including some explicit solutions. In general it is a challenge to construct exact multi-peak traveling wave solutions.
Guoping Zhang
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Periodic Systems Dependent on Parameters

open access: yesJournal of Inequalities and Applications, 2010
This paper is concerned with a periodic system dependent on parameter. We study differentiability with respect to parameters of the periodic solution of the system. Applying a fixed point theorem and the results regarding parameters for C0-semigroups, we
Min He
doaj   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

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