Results 121 to 130 of about 8,371,508 (357)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Periodic solutions of spatially periodic hamiltonian systems

open access: yesJournal of Differential Equations, 1992
The existence of periodic solutions for Hamiltonian systems of ordinary differential equations (1) \(\dot z=J(H_ z(z,t)+f(t))\) is studied, where \(H: R^{2n}\times R\to R\) is of class \(C^ 1\) and is \(2\pi\)-periodic with respect to \(t\); \(f: R\to R\) is continuous and \(2\pi\)-periodic and \(J=\bigl({0 \atop I_ n} {-I_ n \atop 0}\bigr)\).
openaire   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Existence of Periodic and Almost Periodic Solutions of Abstract Retarded Functional Difference Equations in Phase Spaces

open access: yesAdvances in Difference Equations, 2009
The existence of periodic, almost periodic, and asymptotically almost periodic of periodic and almost periodic of abstract retarded functional difference equations in phase spaces is obtained by using stability properties of a bounded solution.
Claudio Vidal
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Periodic Systems Dependent on Parameters

open access: yesJournal of Inequalities and Applications, 2010
This paper is concerned with a periodic system dependent on parameter. We study differentiability with respect to parameters of the periodic solution of the system. Applying a fixed point theorem and the results regarding parameters for C0-semigroups, we
Min He
doaj   +1 more source

Periodic Solution of a Periodic Neutral Delay Equation

open access: yesJournal of Mathematical Analysis and Applications, 1997
The paper deals with the existence of positive periodic solutions of the equation \[ N'(t)= N(t)\Biggl[a(t)- \sum^n_{j= 1}b_j(t)N(t-\sigma_j)- \sum^n_{j= 1}c_j(t)N'(t-\tau_j)\Biggr],\tag{1} \] where \(a\), \(b_j\), \(c_j\), \(j= 1,2,\dots, n\) are positive continuous functions periodic with period \(\omega>0\) and \(\sigma_j\), \(\tau_j\), \(j= 1,2 ...
openaire   +2 more sources

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