Results 51 to 60 of about 15,236 (250)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Existence of Periodic and Almost Periodic Solutions of Abstract Retarded Functional Difference Equations in Phase Spaces

Advances in Difference Equations, 2009
The existence of periodic, almost periodic, and asymptotically almost periodic of periodic and almost periodic of abstract retarded functional difference equations in phase spaces is obtained by using stability properties of a bounded solution.
Vidal Claudio
doaj   +2 more sources

Existence of Periodic and Subharmonic Solutions for Second-Order p-Laplacian Difference Equations

Advances in Difference Equations, 2007
We obtain a sufficient condition for the existence of periodic and subharmonic solutions of second-order p-Laplacian difference equations using the critical point theory.
Peng Chen, Hui Fang
doaj   +1 more source

The Periodic Solutions of Nonlinear Differential Difference Equations

Journal of Mathematical Analysis and Applications, 1994
The existence of slowly oscillating periodic solutions and rapidly oscillating solutions to a class of differential difference equations is considered. Sufficient conditions under which the equations have at least \(N\) or an infinite number of nonconstant periodic solutions are established. For example, it is shown that if \(ah > {\pi \over 2}\), then
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Reverse-Order Lower and Upper Functions for Periodic Problems of Second-Order Singular Difference Equations

Abstract and Applied Analysis, 2013
We present sufficient conditions ensuring the lower and upper functions on the reversed-order for the periodic difference equations. This enables us to obtain the existence of positive periodic solutions of the second-order difference equation where ...
Yanqiong Lu, Ruyun Ma
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Periodic solutions of a discrete-time diffusive system governed by backward difference equations

Advances in Difference Equations, 2005
A discrete-time delayed diffusion model governed by backward difference equations is investigated. By using the coincidence degree and the related continuation theorem as well as some priori estimates, easily verifiable sufficient criteria are ...
Jiezhong Zou, Binxiang Dai
doaj   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Existence of periodic solutions for higher-order nonlinear difference equations

Electronic Journal of Differential Equations, 2016
In this article, we study a higher-order nonlinear difference equation. By using critical point theory, we establish sufficient conditions for the existence of periodic solutions.
Jianhua Leng
doaj