Results 131 to 140 of about 25,043 (257)

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Descriptive Analysis of Periodontitis Case Detection and Selected Comorbidities in Danish Private Dental Practices

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 214-221, February 2026.
ABSTRACT Aim To determine (i) the parameters used by dental professionals to evaluate patients with periodontitis, (ii) the prevalence of periodontitis using different case definitions and (iii) associations between periodontitis and diabetes mellitus, cardiovascular disease and rheumatoid arthritis among adult patients in private practices in Denmark.
Simranjit Kaur, Peter Riis Hansen, Claus Henrik Nielsen, Palle Holmstrup, Anne Havemose‐Poulsen, Merete Markvart, Nikoline Nygaard, Christian Damgaard   +7 more
wiley   +1 more source

Automatic Adaptive and Targeted Localized Refinement in Transient Structural Dynamic Simulations Using the Multiresolution Finite Wavelet Domain Method

International Journal for Numerical Methods in Engineering, Volume 127, Issue 1, 15 January 2026.
ABSTRACT The multiresolution finite wavelet domain method has been meticulously studied in numerous wave propagation simulations, showing excellent convergence properties and very fast computing times. The multiresolution procedure always starts with the coarse solution, and then finer solutions can be superimposed on the coarse solution until ...
Dimitris Dimitriou, Katerina Samara, Dimitris Saravanos   +2 more
wiley   +1 more source

All-Time Existence of Smooth Solutions to PDEs of Mixed Type and the Invariant Subspace of Uniform States

, 1995
T. Hagstrom, J. Lorenz
semanticscholar   +1 more source

Real‐Time Optimal Control of High‐Dimensional Parametrized Systems by Deep Learning‐Based Reduced Order Models

International Journal for Numerical Methods in Engineering, Volume 127, Issue 1, 15 January 2026.
ABSTRACT Steering a system towards a desired target in a very short amount of time is a challenging task from a computational standpoint. Indeed, the intrinsically iterative nature of optimal control problems requires multiple simulations of the state of the physical system to be controlled. Moreover, the control action needs to be updated whenever the
Matteo Tomasetto, Andrea Manzoni, Francesco Braghin   +2 more
wiley   +1 more source

Inverse Design in Nanophotonics via Representation Learning

Advanced Optical Materials, Volume 14, Issue 1, 9 January 2026.
This review frames machine learning (ML) in nanophotonics through a classification based on where ML is applied. We categorize methods as either output‐side, which create differentiable surrogates for solving Maxwell's partial differential equations (PDEs), or input‐side, which learn compact representations of device geometry.
Reza Marzban, Ali Adibi, Raphaël Pestourie   +2 more
wiley   +1 more source

Forced Periodic Reactor Operation Applied to Methanol Synthesis

ChemCatChem, Volume 18, Issue 2, 28 January 2026.
Forced periodic operation of methanol synthesis is studied theoretically and experimentally considering an industrial Cu/ZnO/Al2O3 catalyst. The nonlinear frequency response method and rigorous mathematical optimization predict attractive forcing parameters.
Lothar Kaps, Wieland Kortuz, Johannes Leipold, Carsten Seidel, Matthias Felischak, Tanya Wolff, Menka Petkovska, Dalibor Marinković, Daliborka Nikolić, Achim Kienle, Andreas Seidel‐Morgenstern   +10 more
wiley   +1 more source

No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Lan Gao, Hongqi Xue, Borje Darpo, Kimberly Ingalls, Diksha Kaushik, Neil Smith, Ronald Kong, Lee Golden   +7 more
wiley   +1 more source

Poroelasticity derived from the microstructure for intrinsically incompressible constituents. [PDF]

Z Angew Math Phys
Penta R, Lonati C, Miller L, Marzocchi A.   +3 more
europepmc   +1 more source

Dynamic boundary conditions with noise for an energy balance model coupled to geophysical flows

Mathematische Nachrichten, Volume 299, Issue 1, Page 60-84, January 2026.
Abstract This paper investigates a Sellers‐type energy balance model coupled to the primitive equations by a dynamic boundary condition with and without noise on the boundary. It is shown that this system is globally strongly well‐posed both in the deterministic setting for arbitrary large data in W2(1−1/p),p$W^{2(1-\nicefrac {1}{p}),p}$ for p∈[2,∞)$p \
Gianmarco Del Sarto, Matthias Hieber, Tarek Zöchling   +2 more
wiley   +1 more source