Results 161 to 170 of about 86,877,915 (235)

Data-driven, ML-assisted approaches to problem well-posedness. [PDF]

PNAS Nexus
Bertalan T, Kevrekidis GA, Koronaki ED, Mishra S, Rebrova E, Kevrekidis IG.   +5 more
europepmc   +1 more source

What Causes Geographic Variation in Drug Prescribing? Evidence from Physician Migration

The RAND Journal of Economics, Volume 57, Issue 3, Page 601-626, Autumn (Fall) 2026.
ABSTRACT In this article, we examine the importance of individual physicians in explaining the significant variation in prescription drug spending in Medicare Part D. By tracking prescribing behavior before and after physician relocations, we find that movers' prescribing converges toward the average of their new location.
David Beheshti, Seth Neller
wiley   +1 more source

Dynamical behavior of analytic solutions of the generalized derivative nonlinear Schrödinger equation under stochastic perturbations in fiber communication systems. [PDF]

Sci Rep
Murad MAS, Abdullah AR, Mustafa MA, Hussain E.   +3 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Homogenised balance equations for nematic liquid crystal flow in elastic porous media. [PDF]

Z Angew Math Phys
Alwady M, Mottram NJ, Penta R.
europepmc   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Hamiltonian simulation for nonlinear partial differential equation by Schrödingerization. [PDF]

Sci Rep
Sasaki S, Endo K, Muramatsu M.
europepmc   +1 more source

Unveiling the role of the venous system in arterial hypertension: A computational study

The Journal of Physiology, Volume 604, Issue 17, Page 7145-7160, 1 September 2026.
Abstract figure legend This abstract figure summarizes the principal findings of our computational analysis of hypertension. Model‐based results identify reduced venous compliance as a major determinant of elevated arterial pressure, second only to increased peripheral resistance.
Eleuterio F. Toro, Lucas O. Müller, Tonja W. Emans, Fiona D. McBryde, Julian F. R. Paton   +4 more
wiley   +1 more source

Analytical methods and Riccati neural networks method of Kudryashov's quintuple self-phase modulation with dual-form of generalized nonlocal nonlinearity. [PDF]

Sci Rep
Yu D, Manafian J, Abdalrahem MK, Lakestani M, Ilhan OA, Malmir S, Nuray R, Hammadi AH.   +7 more
europepmc   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source