Results 81 to 90 of about 23,176 (145)

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, EarlyView.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

The non‐hydrostatic option of the ECMWF global weather forecast model: Improvements for kilometre‐scale modelling

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study presents improvements to the non‐hydrostatic version of the European Centre for Medium‐Range Weather Forecasts (ECMWF) Integrated Forecasting System (IFS), enabling stable global simulations at 1.4‐km resolution. A systematic comparison with the hydrostatic version at resolutions from 9 to 1.4 km shows that non‐hydrostatic effects emerge in ...
Jozef Vivoda, Inna Polichtchouk, Michail Diamantakis, Filip Váňa   +3 more
wiley   +1 more source

Accurate macroscale modelling of spatial dynamics in multiple dimensions

, 2012
Developments in dynamical systems theory provides new support for the macroscale modelling of pdes and other microscale systems such as Lattice Boltzmann, Monte Carlo or Molecular Dynamics simulators.
Bunder, J. E., MacKenzie, Tony, Roberts, A. J.   +2 more
core  

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Conservation law, Chupin Liu’s theorem and propagation of pulses in optical metamaterials modeled by NLSE with power law nonlinearity

Scientific Reports
This paper devote to investigate plenteous optical and other soliton solutions to the generalized nonlinear Schrödinger equation with the parabolic nonlinear (NL) law by employing two analytical techniques. The analytical schemes are the improved $$\exp (
He Zhu, Jalil Manafian, Alaa Hussein Hammadi, Onur Alp Ilhan, Mehrdad Lakestani, Somaye Malmir, K. H. Mahmoud   +6 more
doaj   +1 more source

Fault‐Tolerant Fuzzy Boundary Control for Nonlinear Distributed Parameter Systems Under Limited Measurements and Markovian Failures

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This paper proposes a boundary control method for nonlinear distributed parameter systems (DPSs) with limited boundary measurements (BMs), as typically encountered in networked cyber‐physical processes with spatially distributed dynamics such as thermal and biomedical diffusion systems.
Yanlin Li, Kaibo Shi, Yue Yu, Xiangkun Wang, Ming Zhu, Xiao Cai   +5 more
wiley   +1 more source

Periodic solutions to PDEs with fractional diffusion

, 2016
The aim of this Bachelor's Thesis is the study of periodic solutions to nonlinear equations involving the fractional Laplace operator. Our starting point is the Benjamin-Ono equation in water waves, a completely integrable nonlinear problem in one dimension.
openaire   +1 more source

Practical Day‐Ahead Gas Generator Dispatch Optimisation for Enhancing the Reserved Capacity

IET Smart Energy Systems, EarlyView.
Practical day‐ahead gas generator dispatch optimisation model is proposed to enhance the system reserved capacity. ABSTRACT In order to reduce carbon dioxide emissions, traditional coal‐fired power generation has been strictly limited in China recently, which has led to the problem of reserved capacity shortage. As one of the critical east provinces of
Shengyuan Liu, Yicheng Jiang, Wei Gu, Wenduo Sun, Bin Feng, Gang Huang, Yunchu Wang   +6 more
wiley   +1 more source

Beyond the next step: A multi‐criteria generative validation framework for step selection functions

Methods in Ecology and Evolution, EarlyView.
Abstract Step‐selection functions (SSFs), typically fitted using step‐selection analysis (SSA) or integrated step‐selection analysis (iSSA) are widely used to infer habitat selection and movement kernels from high‐frequency telemetry data, but most standard validation tools focus on one‐step‐ahead prediction and do not guarantee that fitted models ...
Aurélien Nicosia
wiley   +1 more source

Exploring novel solitary wave phenomena in Klein–Gordon equation using $$\phi ^{6}$$ ϕ 6 model expansion method

Scientific Reports
In this study, the $$\phi ^{6}$$ ϕ 6 -model expansion method is showed to be useful for finding solitary wave solutions to the Klein–Gordon (KG) equation.
Yasir A. Madani, Khidir Shaib Mohamed, Sadia Yasin, Sehrish Ramzan, Khaled Aldwoah, Mohammed Hassan   +5 more
doaj   +1 more source