Results 101 to 110 of about 23,176 (145)

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

Transfusion, EarlyView.
Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn, Felix Korell, Angela Hückelhoven‐Krauss, Brigitte Neuber, Miriam Stenzinger, Anita Ludwig‐Husemann, Maria‐Luisa Schubert, Patrick Derigs, Kiavasch Farid, Tim Sauer, Sandra Sauer, Carsten Müller‐Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt   +14 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Building a Digital Twin for Material Testing: Model Reduction and Data Assimilation

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT The rapid advancement of industrial technologies, data collection, and handling methods has paved the way for the widespread adoption of digital twins (DTs) in engineering, enabling seamless integration between physical systems and their virtual counterparts.
Rubén Aylwin, Nina Beranek, Gajendra Babu Budihala, Matthias Mettenleiter, Goksu Oruc, Karsten Urban   +5 more
wiley   +1 more source

A Compact Algorithm for Applying Periodic Boundary Conditions in 3D RVE Modeling with Abaqus

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT Periodic boundary conditions (PBCs) are essential in multiscale modeling for computing the effective properties of heterogeneous materials via representative volume elements (RVEs). While several automated solutions have been developed for implementing PBCs in finite element software, many rely on structured node classification and predefined ...
Reza Sadeghpour, Martin Kraska
wiley   +1 more source

Two Scale FE‐FFT‐Based Modeling of Cancellous Bone

Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT Osteoporosis is characterized by a loss of volume percentage of cortical bone, which reduces the loading capacity of this organ and increases its likelihood for fractures. The disease has the highest prevalence of any bone disease worldwide, with a particularly high incidence among the elderly.
Mischa Blaszczyk, Christian Gierden, Klaus Hackl, Johanna Waimann   +3 more
wiley   +1 more source

Advances in Erectile Dysfunction Management: What Does Work

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent and multifactorial disorder that substantially affects quality of life. Pathophysiology includes vascular, neurogenic, drug‐induced, and psychogenic causes, and frequently coexists with cardiometabolic disease.
Jolie Shen, Daye Park, Jasper Bash, Juan Andino   +3 more
wiley   +1 more source

Emerging Treatments for Erectile Dysfunction

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent condition that can significantly affect men's sexual health and quality of life, and for which there are many well‐studied effective treatments. In spite of this, many individuals still seek out alternative therapies.
Resa Magill, Jeff Morrison, Juan Andino, Jasper Bash   +3 more
wiley   +1 more source

Interaction of Dirac δ$$ \delta $$‐Waves in the Inviscid Levine and Sleeman Chemotaxis Model

Mathematical Methods in the Applied Sciences, Volume 49, Issue 7, Page 6492-6506, 15 May 2026.
ABSTRACT This article investigates interactions of δ$$ \delta $$‐shock waves in the inviscid Levine and Sleeman chemotaxis model ut−λ(uv)x=0$$ {u}_t-\lambda {(uv)}_x=0 $$, vt−ux=0$$ {v}_t-{u}_x=0 $$. The analysis employs a distributional product and a solution concept that extends the classical solution concept.
Adelino Paiva
wiley   +1 more source