Results 91 to 100 of about 337,853 (263)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Editorial: Celebrating the International Year of the Periodic Table: Beyond Mendeleev 150
Frontiers in Chemistry, 2020 Mikhail V. Kurushkin +2 more
doaj +1 more source
Periodic Solutions of Multispecies Mutualism System with Infinite Delays
Abstract and Applied Analysis, 2014 We studied the delayed periodic mutualism system with Gilpin-Ayala effect. Some new and interesting sufficient conditions are obtained to guarantee the existence of periodic solution for the multispecies mutualism system with infinite delays.
Wenbo Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Some Interesting Bifurcations of Nonlinear Waves for the Generalized Drinfel’d-Sokolov System
Abstract and Applied Analysis, 2014 We study the bifurcations of nonlinear waves for the generalized Drinfel’d-Sokolov system ut+(vm)x=0,vt+a(vn)xxx+buxv+cuvx=0 called D(m,n) system. We reveal some interesting bifurcation phenomena as follows. (1) For D(2,1) system, the fractional solitary
Huixian Cai, Chaohong Pan, Zhengrong Liu
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Asymptotic Behavior of a Periodic Diffusion System
Journal of Inequalities and Applications, 2010 We study the asymptotic behavior of the nonnegative solutions of a periodic reaction diffusion system. By obtaining a priori upper bound of the nonnegative periodic solutions of the corresponding periodic diffusion system, we establish the existence of ...
Li Songsong, Hui Xiaofeng
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Periodic Solution for Nonlinear System of Differential Equations Depending on The Gamma Distribution
Science Journal of University of Zakho, 2014 In this paper we study the periodic solution of nonlinear system of differential equations depending on the gamma distribution by using the numerical analytic method to investigate periodic solutions of ordinary differential equation which given by ...
Raad N. Butris
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