Results 101 to 110 of about 319,594 (315)

Comment interpréter une revue ? Quelques pistes de lecture

open access: yesContextes, 2008
In this article, I study the “meaning” of a periodical, in two related ways: on the one hand I consider the “internal” interpretation of a periodical, on the other hand I look at its “external” impact.
Francis Mus
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

To the 25th anniversary of the scientific journal “Agricultural Science Euro-North-East”

open access: yesАграрная наука Евро-Северо-Востока
The publication informs on the main stages of establishment and development of the scientific journal “Agricultural Science Euro-North-East” of the Federal Agricultural Research Center of the North-East named N. V.
V. А. Sysuev, N. Е. Rubtsova
doaj  

Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis

open access: yesFrontiers in Pharmacology
Objectives: Amidst rising global burden of depression and the associated challenges with conventional antidepressant therapies, there is a growing interest in exploring the efficacy and safety of alternative treatments. This study uses a Bayesian network
Chun Dang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Periodic monopoles

open access: yesPhysics Letters B, 2005
This paper deals with static BPS monopoles in three dimensions which are periodic either in one direction (monopole chains) or two directions (monopole sheets). The Nahm construction of the simplest monopole chain is implemented numerically, and the resulting family of solutions described.
openaire   +3 more sources

SP341-F-Periodical Cicadas

open access: yes, 2007
The periodical cicada, Magicicada species, has the longest developmental period of any insect in North America. There is probably no insect that attracts as much attention in eastern North America as does the periodical cicada.
The University of Tennessee Agricultural Extension Service
core  

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