Results 111 to 120 of about 319,594 (315)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Genre features of the bibliographic section in “The Bulletin of the Novgorod Zemstvo”
Studia HumanitatisThe article examines the role and significance of “The Bulletin of the Novgorod Zemstvo” as an example of regional periodicals in Russia at the end of the 19th and the beginning of the 20th centuries.
Barashkova Daria Sergeevna
doaj
Notre Dame Journal of Formal Logic, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Portholes, channels, and seductions: the messy affordances of Antipodean periodical scholarship
, 2021 In a well-known essay in published in The New Left Review in 2000, Franco Moretti called for a new approach to literary history that would capture the enormous abundance and variety of world literature.
Kuttainen, Victoria
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 1990 Periodical room (former Faculty Dining Room), 1st floor of Welch Hall, circa 1990shttps://digitalcommons.rockefeller.edu/welch-hall/1025/thumbnail ...
The Rockefeller University
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Western language books in the Beijing Library: criteria for acquisition and the method of selection [PDF]
, 1999 Each year, the National Library of China acquires about 20,000 English language books, about 2,000 each of German and French and a small number of Spanish, Italian and Romanian books.
Gu, Ben
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