Results 71 to 80 of about 28,993 (266)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Manual search approaches used by systematic reviewers in dermatology

Journal of the Medical Library Association, 2017
Objective: Manual searches are supplemental approaches to database searches to identify additional primary studies for systematic reviews. The authors argue that these manual approaches, in particular hand-searching and perusing reference lists, are ...
Matt Vassar, Paul Atakpo, Melissa J. Kash   +2 more
doaj   +1 more source

Ukrainian Topics in Slovak Periodicals at Turn of the 20th Century

Академічний журнал "Слово і Час", 2019
The article focuses on the representation of Ukrainian topics in Slovak journals, mainly in “Hlas” (‘Voice’). This periodical had a subtitle “Mesačník pre literatúru, politika a sociálne otázky” (Monthly on literature, politics and social issues) and appeared in 1898–1904.  “Hlas” is considered to be the publishing platform of liberally oriented Slovak
Luybica Babotova, Andrea Draganová
openaire   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Why Do We Reject So Many Articles in Acta Médica Portuguesa?

Acta Médica Portuguesa
N ...
Tiago Villanueva, Helena Donato
doaj   +1 more source

Letter to the Editor: More on Conflict of Interest Disclosure in a Top-Tier Portuguese Medical Journal

Acta Médica Portuguesa, 2018
Not Applicable.
João Gama Marques
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Análise da produção científica da Revista Brasileira de Geriatria e Gerontologia: uma revisão bibliométrica

Revista Brasileira de Geriatria e Gerontologia
OBJETIVO: Descrever e analisar o perfil das publicações da Revista Brasileira de Geriatria e Gerontologia (RBGG) no período de 2006 a 2013. MÉTODO: Trata-se de pesquisa de revisão bibliográfica, do tipo descritivo, com análise bibliométrica da ...
Javier Jerez-Roig, Marcello Barbosa Otoni Gonçalves Guedes, João Maria Dias e Silva, Kenio Costa de Lima   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source