Results 71 to 80 of about 28,481 (266)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Manual search approaches used by systematic reviewers in dermatology

Journal of the Medical Library Association, 2017
Objective: Manual searches are supplemental approaches to database searches to identify additional primary studies for systematic reviews. The authors argue that these manual approaches, in particular hand-searching and perusing reference lists, are ...
Matt Vassar, Paul Atakpo, Melissa J. Kash   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Why Do We Reject So Many Articles in Acta Médica Portuguesa?

Acta Médica Portuguesa
N ...
Tiago Villanueva, Helena Donato
doaj   +1 more source

Letter to the Editor: More on Conflict of Interest Disclosure in a Top-Tier Portuguese Medical Journal

Acta Médica Portuguesa, 2018
Not Applicable.
João Gama Marques
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Ukrainian Topics in Slovak Periodicals at Turn of the 20th Century

Академічний журнал "Слово і Час", 2019
The article focuses on the representation of Ukrainian topics in Slovak journals, mainly in “Hlas” (‘Voice’). This periodical had a subtitle “Mesačník pre literatúru, politika a sociálne otázky” (Monthly on literature, politics and social issues) and appeared in 1898–1904.  “Hlas” is considered to be the publishing platform of liberally oriented Slovak
Luybica Babotova, Andrea Draganová
openaire   +2 more sources

Análise da produção científica da Revista Brasileira de Geriatria e Gerontologia: uma revisão bibliométrica

Revista Brasileira de Geriatria e Gerontologia
OBJETIVO: Descrever e analisar o perfil das publicações da Revista Brasileira de Geriatria e Gerontologia (RBGG) no período de 2006 a 2013. MÉTODO: Trata-se de pesquisa de revisão bibliográfica, do tipo descritivo, com análise bibliométrica da ...
Javier Jerez-Roig, Marcello Barbosa Otoni Gonçalves Guedes, João Maria Dias e Silva, Kenio Costa de Lima   +3 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source