Results 31 to 40 of about 136,735 (253)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Nonlinear Behavior Characterization of a 3-Layer Laminated Cantilever Beam System
Nonlinear Engineering, 2014 This research aims to characterize the nonlinear responses of a 3-layer laminated composite cantilever beam systemsubjected to evenly distributed dynamic excitations, with the employment of the Periodicity Ratio (PR) method.
Dai Liming +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Qualitative Properties of Nonlinear Neutral Transmission Line Models and Their Applications
AxiomsNeutral transmission line models are essential for analyzing stability and periodicity in systems influenced by nonlinear and delayed dynamics, particularly in modern smart grids.
Mouataz Billah Mesmouli +6 more
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Methods for Periodicity Search
, 2022 Presentation presented in class about periodicity search ...
Zucker, Shay
core +1 more source
Periodicity on isolated time scales [PDF]
, 2022 In this work, we formulate the definition of periodicity for functions defined on isolated time scales. The introduced definition is consistent with the known formulations in the discrete and quantum calculus settings. Using the definition of periodicity,
Bohner, Martin +5 more
core +1 more source
Global dynamics of a dengue fever model incorporating transmission seasonality
Nonlinear Analysis, 2023 The changes of seasons cause that the transmission of dengue fever is characterized by periodicity. We develop a dengue fever transmission model incorporating seasonal periodicity and spatial heterogeneity.
Min Zhu +3 more
doaj +1 more source