Results 71 to 80 of about 108,072 (292)

Targeting keystone species helps restore the dysbiosis of butyrate‐producing bacteria in nonalcoholic fatty liver disease

iMeta, Volume 1, Issue 4, December 2022., 2022
In this study, we applied an algorithm to the keystone species identification in the gut microbiome, based on current causal inference theories and the dynamic intervention simulation. We identified the nonalcoholic steatohepatitis (NASH) keystone species combination, represented by Porphyromonas loveana, Alistipes indistinctus, and Dialister ...
Dingfeng Wu, Lei Liu, Na Jiao, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu, Rohit Loomba, Ruixin Zhu   +9 more
wiley   +1 more source

Adjusting for informative cluster size in pseudo-value based regression approaches with clustered time to event data [PDF]

arXiv, 2022
Informative cluster size (ICS) arises in situations with clustered data where a latent relationship exists between the number of participants in a cluster and the outcome measures. Although this phenomenon has been sporadically reported in statistical literature for nearly two decades now, further exploration is needed in certain statistical ...
arxiv  

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

Automated Process Incorporating Machine Learning Segmentation and Correlation of Oral Diseases with Systemic Health [PDF]

arXiv, 2018
Imaging fluorescent disease biomarkers in tissues and skin is a non-invasive method to screen for health conditions. We report an automated process that combines intraoral fluorescent porphyrin biomarker imaging, clinical examinations and machine learning for correlation of systemic health conditions with periodontal disease. 1215 intraoral fluorescent
arxiv  

Use of the Deep Learning Approach to Measure Alveolar Bone Level [PDF]

arXiv, 2021
Abstract: Aim: The goal was to use a Deep Convolutional Neural Network to measure the radiographic alveolar bone level to aid periodontal diagnosis. Material and methods: A Deep Learning (DL) model was developed by integrating three segmentation networks (bone area, tooth, cementoenamel junction) and image analysis to measure the radiographic bone ...
arxiv  

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

Advances in understanding vitamin D deficiency as a risk factor in periodontal disease management

Journal of Mind and Medical Sciences
This study investigates the relationship between periodontal disease and vitamin D deficiency by correlating clinical periodontal parameters with serum levels of vitamin D; (2) Methods: Data from the literature and the periodontal status of two ...
Marina Cristina Giurgiu, George Alexandru Denis Popescu, Stana Paunica, Dragos Nicolae Ciongaru, Brandusa Florina Mocanu, Ana Maria Alexandra Stanescu, Anca Silvia Dumitriu   +6 more
doaj   +1 more source

OXIDATIVE STRESS AND PERIODONTAL DISEASE. REVIEW

Romanian Journal of Medical and Dental Education, 2018
ROS (reactive oxygen species) have become increasingly worthy of attention because of their central role in the progression of many inflammatory conditions.
Alexandra Martu, Sorina Solomon, Silvia Martu, Liliana Foia   +3 more
doaj  

Numerical simulation of the stress-strain state of the dental system [PDF]

, 2015
We present mathematical models, computational algorithms and software, which can be used for prediction of results of prosthetic treatment. More interest issue is biomechanics of the periodontal complex because any prosthesis is accompanied by a risk of overloading the supporting elements.
arxiv   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source