Results 201 to 210 of about 3,766,251 (261)

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expansion.
Mira C. Hasner, Faith C. Robertson, Nathaniel D. Sisterson, Gabriel Lazaro‐Munoz, Florence T. Bourgeois, James W. Wheless, Steven M. Wolf, Peter C. Warnke, Saadi Ghatan, Joffre Olaya, Catherine J. Chu, Brian N. Lundstrom, Sanjeev V. Kothare, Marytery Fajardo, Marike L. D. Broekman, R. Mark Richardson   +15 more
wiley   +1 more source

Perils and progress in epilepsy surgery utilization: Twenty‐five years later

Epilepsia, EarlyView.
Abstract More than 25 years have passed since the first randomized controlled trial (RCT) established that surgery is superior to continued anti‐seizure medication (ASM) for drug‐resistant temporal lobe epilepsy, and nearly as long since a joint practice parameter urged that appropriate surgical candidates be referred to a specialized center for ...
Dario J. Englot
wiley   +1 more source

Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms

Epilepsia, EarlyView.
Abstract Objective Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual‐related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about‐monthly cycles, present in both men and women, further confound the ...
Victoria Wong, Ewan S. Nurse, Ashley Reynolds, Mark J. Cook, Philippa J. Karoly   +4 more
wiley   +1 more source

Multimodal modeling of the ictal onset zone in refractory insular epilepsy and seizure outcome of magnetic resonance‐guided laser interstitial therapy: A pediatric single‐center retrospective study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate seizure outcomes after magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) in children with insular epilepsy and to assess how the extent of ablation overlaps with multimodal definitions of the ictal onset zone (IOZ).
Lelio Guida, Emma Losito, Sebastian Rodrigo, Catherine Chiron, Ludovic Fillon, Marie Bourgeois, Anna Kaminska, Johan Pallud, Nicole Chemaly, Volodia Dangouloff‐Ross, Stephane Auvin, Blandine Dozieres, Rima Nabbout, Olivier David, Nathalie Boddaert, Thomas Blauwblomme   +15 more
wiley   +1 more source

Cost‐effectiveness of laser interstitial thermal therapy vs. anterior temporal lobectomy for drug‐resistant mesial temporal lobe epilepsy: A decision analytic model

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the comparative cost‐effectiveness of anterior temporal lobectomy (ATL) and magnetic resonance–guided laser interstitial thermal therapy (LITT) in patients with drug‐resistant mesial temporal lobe epilepsy (mTLE). Methods A decision‐analytic model was constructed to simulate the risks, benefits, and costs of ATL versus ...
Zhihao Guo, Yihe Wang, Kailiang Wang, Yongzhi Shan, Guoguang Zhao   +4 more
wiley   +1 more source

Clinical efficacy and cost‐effectiveness of epilepsy surgery in low‐ and middle‐income countries: A systematic review and meta‐analysis

Epilepsia Open, EarlyView.
Abstract Objective To synthesize evidence on clinical outcomes, direct surgical costs, and cost‐effectiveness of resective epilepsy surgery for drug‐resistant epilepsy in low‐ and middle‐income countries (LMICs). Methods MEDLINE, PubMed, Scopus, and the Cochrane Library were searched through May 17, 2026.
Muhamad Thohar Arifin, Firman Pribadi, Nurettin Öner   +2 more
wiley   +1 more source

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Outcomes in perioperative care

Current Opinion in Anaesthesiology, 2010
The present review examines the trends and controversies on how perioperative care can influence outcome after anesthesia and surgery.Recent studies indicate that anesthesia and perioperative care may have a major impact on long-term postoperative mortality and major complications in surgical patients by decreasing the rate of individual decisions. The
Jean, Mantz, Souhayl, Dahmani, Catherine, Paugam-Burtz   +2 more
openaire   +2 more sources

Measuring perioperative outcome

Current Opinion in Anaesthesiology, 2016
Measuring clinically relevant and patient-centered perioperative outcomes provides the knowledge that enables clinicians to optimize their practice and guide shared decision-making, researchers to set a future agenda and policymakers to prioritize healthcare spending.A large international collaboration is currently working to define a set of core ...
Mark, Shulman, Paul, Myles
openaire   +2 more sources

Regional anaesthesia and perioperative outcome

Current Opinion in Anaesthesiology, 2006
The ongoing debate on the outcome benefits of regional anaesthesia and analgesia over general anaesthesia and systemic analgesia has led to a large number of recently published papers, in particular systematic reviews and meta-analyses that justify a review of the current status of the debate.Meta-analyses have shown consistently improved analgesia ...
Evangelos, Tziavrangos, Stephan A, Schug
openaire   +2 more sources

Perioperative outcome in sarcoma surgery

Langenbeck's Archives of Surgery, 2006
Soft tissue sarcomas (STS) are rare tumors accounting for less than 1% of all malignancies. Although disease-specific surgical management is increasingly important, only few data are available for STS. Here, we analyze a single institution setting focusing on perioperative surgical and clinical parameters.Prospectively gathered data of all adult ...
Moritz N, Wente, Matthias H M, Schwarzbach, Ulf, Hinz, Christine, Leowardi, Gunhild, Mechtersheimer, Robert, Krempien, Gerlinde, Egerer, Helmut, Friess, Markus W, Büchler   +8 more
openaire   +2 more sources