Results 51 to 60 of about 5,166,504 (245)

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

SHOULD STATINS BE DISCONTINUED IN PERI-OPERATIVE PERIOD?

Вестник анестезиологии и реаниматологии, 2018
HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors, which are more known as statins, reduce the level of low density lipoproteids and total cholesterol in blood plasma.
V. V. Lomivorotov, S. M. Efremov, M. N. Abubakirov, D. N. Merekin   +3 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Unlocking Insights: A Survey on Perioperative Hemodynamic Monitoring in Kidney Transplantation Across India

Indian Journal of Transplantation
Objective: Across the globe, kidney transplant is the most frequently performed transplant surgery. Suboptimal hemodynamic monitoring in the perioperative period results in poor graft and patient outcomes.
Vipin Kumar Goyal, Saurabh Mittal, Praveenkumar Shekhrajka   +2 more
doaj   +1 more source

Pharmacologic agents for acute hemodynamic instability: Recent advances in the management of perioperative shock- A systematic review

Annals of Cardiac Anaesthesia, 2015
Despite the growing body of evidence evaluating the efficacy of vasoactive agents in the management of hemodynamic instability and circulatory shock, it appears no agent is superior. This is becoming increasingly accepted as current guidelines are moving
Steven T Morozowich, Harish Ramakrishna
doaj   +1 more source

Exploring wellbeing and turnover intention among perioperative nurses: A discussion paper [PDF]

In the perioperative environment, the safety and wellbeing of nursing staff are paramount for ensuring the delivery of high-quality, safe and sustainable health care services.
Ada Xie, Grace Xu, Duff, Jed, Xie, A, Xu, G, Xie, Ada, Jed Duff, Xu, Grace, https://orcid.org/, Duff, J   +9 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Massage in the application of perioperative medicine: research hotspots and trends

Frontiers in Medicine
BackgroundOver the past decade, the application of massage in the perioperative period has attracted the interest of researchers worldwide, with a relatively stable volume of literature published annually.ObjectiveBy conducting a bibliometric analysis of
Xiaoqin Li, Chuan You, Haige Wei, Huan Li, Yun Liang, Yun Liang   +5 more
doaj   +1 more source

Thermoregulation and its disorders in the children’s perioperative period

Journal of Education, Health and Sport, 2019
Disorders of termoregulation is a phenomeon that can occur as a result of any kind of anaesthesia. In the perioperative period, infants and small children are most exposed to significant and dangerous changes in body temperature, especially hypothermia ...
Barbara Dobrowoska-Czopor, Agnieszka Paula Maj, Izabela Czykieta   +2 more
doaj   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source