Results 1 to 10 of about 3,916,198 (252)

The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy

Biomedicines, 2022
Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the
Hye-Ji Jang, Young-Yeon Kim, Kang-Min Lee, Jung-Eun Shin, Jeanho Yun   +4 more
doaj   +1 more source

Peripheral mechanisms of peripheral neuropathic pain

Frontiers in Molecular Neuroscience, 2023
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is an increasing and urgent need for new therapies for treating this disorder.
Paola Pacifico, James S. Coy-Dibley, Richard J. Miller, Daniela M. Menichella   +3 more
openaire   +3 more sources

The “needle re-entry” technique for infrainguinal arterial calcified occlusive lesions

CVIR Endovascular, 2021
Background Vascular calcification is a predictor of poor clinical outcome during and after endovascular intervention. Guidewire crossing techniques and devices have been developed, but chronic total occlusions (CTOs) with severe calcification often ...
Takuya Haraguchi, Yoshifumi Kashima, Masanaga Tsujimoto, Tomohiko Watanabe, Hidemasa Shitan, Takuro Sugie, Daisuke Hachinohe, Umihiko Kaneko, Ken Kobayashi, Daitaro Kanno, Katsuhiko Sato, Tsutomu Fujita   +11 more
doaj   +1 more source

The “Direct tip injection in occlusive lesions (DIOL)” fashion

CVIR Endovascular, 2021
Background The successful intervention for peripheral artery disease is limited by complex chronic total occlusions (CTOs). During CTO wiring, without the use of intravascular or extravascular ultrasound, the guidewire position is unclear, except for ...
Takuya Haraguchi, Tsutomu Fujita, Yoshifumi Kashima, Masanaga Tsujimoto, Tomohiko Watanabe, Takuro Sugie, Daisuke Hachinohe, Umihiko Kaneko, Ken Kobayashi, Daitaro Kanno, Katsuhiko Sato   +10 more
doaj   +1 more source

The “Fracking” technique: a novel approach to crack deep calcified plaque in the common femoral artery with hydraulic pressure

CVIR Endovascular, 2021
Background The patency achieved by conventional peripheral interventions for atherosclerotic lesions in the common femoral artery (CFA), called the “no stenting zone”, is not superior to that achieved by surgical endarterectomy due to calcified plaque ...
Takuya Haraguchi, Tsutomu Fujita, Yoshifumi Kashima, Masanaga Tsujimoto, Tsuyoshi Takeuchi, Yutaka Tadano, Daisuke Hachinohe, Umihiko Kaneko, Ken Kobayashi, Daitaro Kanno, Katsuhiko Sato   +10 more
doaj   +1 more source

Necrotizing fasciitis of the thigh due to a secondary aortoduodenal fistula

Radiology Case Reports, 2023
Background: Secondary aortoenteric fistula is an iatrogenic complication after aortic reconstructive surgery presenting with gastrointestinal bleeding and/or infectious symptoms. Infrequently, it may manifest with nonspecific and atypical clinical signs.
Fahd Khefacha, PhD, Aouini Fatma, PhD, Amel Changal, PhD, Raja Taieb, PhD, Chaima Chihaoui, PhD, Haifa Jenni, PhD, Achraf Saaidi, PhD, Mohamed Bechir Khalifa, PhD, Nabil Ben Romdhane, PhD   +8 more
doaj   +1 more source

Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]

, 2016
The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi, A Laroni, A Petrovic, Ada Francia, Alessandra D’Abramo, Alessandra Oliva, Anna Bellizzi, B Engelhardt, BL Padgett, C Bozic, C Tornatore, Claudia D’Agostino, Claudio Maria Mastroianni, D Jing, E Pucci, Elena Anzivino, EM Frohman, EM Johnson, Enrico Millefiorini, EO Major, EO Major, F Serana, F Taguchi, G Defer, H Bonig, K Khalili, L Börnsen, L Gorelik, LJ Marshall, M Niino, Manuela Morreale, Marco Iannetta, Maria Antonella Zingaropoli, Maria Rosa Ciardi, MC Monaco, ME Hemler, P Maenetje, RA Rudick, RM Ransohoff, Robert Shin Fujinami, RR Lobb, S Beltrami, SA Houff, SA Sadiq, Sara Lo Menzo, Simona Pontecorvo, T Van Loy, Valeria Pietropaolo, Vincenzo Vullo, WJ Atwood, Y Chen, Ö Yaldizli   +51 more
core   +13 more sources

Supera Stent Implantation with Ultrasound Guidance for Complex Ostial Lesions of Superficial Femoral Artery by Retrograde Approach: The SUGAR Technique

Journal of Clinical Interventional Radiology ISVIR, 2021
Purpose The aim of this study was to describe a modified technique for accurate deployment of the Supera stent under ultrasound (US) guidance for complex lesions involving superficial femoral artery (SFA) ostium without jailing profunda femoral artery ...
Virender Singh Sheorain, Rajiv Parakh, Tarun Grover, Tapish Sahu, Ashutosh Aher   +4 more
doaj   +1 more source

Deep vein thrombosis due to May-Thurner syndrome: a case report

BMC Cardiovascular Disorders, 2020
Background May-Thurner syndrome (MTS) or Cockett’s syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications of MTS include deep vein thrombus
Yan Meng, Hao Qin, Qiang Ma, Junbo Zhang, Bo Zhang, Honggang Pang, Qian Yin, Hongyan Tian   +7 more
doaj   +1 more source

Development and validation of a prediction model to estimate risk of acute pulmonary embolism in deep vein thrombosis patients

Scientific Reports, 2022
Venous thromboembolism (VTE), clinically presenting as deep vein thrombosis (DVT) or pulmonary embolism (PE). Not all DVT patients carry the same risk of developing acute pulmonary embolism (APE).
You Li, Yuncong He, Yan Meng, Bowen Fu, Shuanglong Xue, Mengyang Kang, Zhenzhen Duan, Yan Chen, Yifan Wang, Hongyan Tian   +9 more
doaj   +1 more source